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E-mail: biomed@csu.edu.cn
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Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.
| Uniprot primary ID | P36888 |
| PDB ID | 4RT7 3QS7 3QS9 1RJB 4XUF |
| DrugBank ID | DB00398 DB09079 DB08901 DB01268 |
| BioGrid ID | 108610 |
| GuidetoPHARMACOLOGY ID | 1807 |
| PharmGKB ID | PA28181 |
| KEGG ID | hsa:2322 |
| DIP ID | DIP-59769N |
| STRING ID | 9606.ENSP00000241453 |
| IntAct ID | P36888 |
| DMDM | 156630887 |
| BRENDA | 2.7.10.1 |
| Reactome | |
| SignaLink | P36888 |
| BioCyc | |
| Entrez Gene (Gene ID) | 2322 |
| BindingDB | P36888 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.865 | 0.005 | 0.825 | 0.005 | 0.845 | 0.005 | 0.850 | 0.000 | 0.910 | 0.000 | 0.692 | 0.004 | Download |
| Estate fingerprints | 0.793 | 0.005 | 0.731 | 0.003 | 0.762 | 0.004 | 0.770 | 0.000 | 0.849 | 0.003 | 0.528 | 0.004 | Download |
| MACCS fingerprints | 0.805 | 0.005 | 0.715 | 0.005 | 0.760 | 0.000 | 0.771 | 0.003 | 0.832 | 0.004 | 0.524 | 0.005 | Download |
| Daylight fingerprints | 0.840 | 0.000 | 0.820 | 0.005 | 0.830 | 0.000 | 0.832 | 0.004 | 0.896 | 0.005 | 0.662 | 0.004 | Download |
| ECFP2 fingerprints | 0.945 | 0.005 | 0.815 | 0.000 | 0.880 | 0.000 | 0.890 | 0.000 | 0.950 | 0.000 | 0.763 | 0.005 | Download |
| ECFP4 fingerprints | 0.879 | 0.003 | 0.929 | 0.005 | 0.904 | 0.005 | 0.901 | 0.003 | 0.965 | 0.005 | 0.808 | 0.006 | Download |
| ECFP6 fingerprints | 0.827 | 0.005 | 0.953 | 0.005 | 0.890 | 0.000 | 0.880 | 0.000 | 0.960 | 0.000 | 0.780 | 0.000 | Download |
| Positive dataset | Negative dataset |
The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
E-mail: biomed@csu.edu.cn
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