Target name

P36888: Receptor-type tyrosine-protein kinase FLT3


  Protein function

Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.

  Database links

Uniprot primary ID P36888
PDB ID 4RT7 3QS7 3QS9 1RJB 4XUF
DrugBank ID DB00398 DB09079 DB08901 DB01268
BioGrid ID 108610
GuidetoPHARMACOLOGY ID 1807
PharmGKB ID PA28181
KEGG ID hsa:2322
DIP ID DIP-59769N
STRING ID 9606.ENSP00000241453
IntAct ID P36888
DMDM 156630887
BRENDA 2.7.10.1
Reactome
SignaLink P36888
BioCyc
Entrez Gene (Gene ID) 2322
BindingDB P36888

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.865 0.005 0.825 0.005 0.845 0.005 0.850 0.000 0.910 0.000 0.692 0.004 Download
Estate fingerprints 0.793 0.005 0.731 0.003 0.762 0.004 0.770 0.000 0.849 0.003 0.528 0.004 Download
MACCS fingerprints 0.805 0.005 0.715 0.005 0.760 0.000 0.771 0.003 0.832 0.004 0.524 0.005 Download
Daylight fingerprints 0.840 0.000 0.820 0.005 0.830 0.000 0.832 0.004 0.896 0.005 0.662 0.004 Download
ECFP2 fingerprints 0.945 0.005 0.815 0.000 0.880 0.000 0.890 0.000 0.950 0.000 0.763 0.005 Download
ECFP4 fingerprints 0.879 0.003 0.929 0.005 0.904 0.005 0.901 0.003 0.965 0.005 0.808 0.006 Download
ECFP6 fingerprints 0.827 0.005 0.953 0.005 0.890 0.000 0.880 0.000 0.960 0.000 0.780 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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