Target name

P37058: Testosterone 17-beta-dehydrogenase 3


  Protein function

Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH.

  Database links

Uniprot primary ID P37058
PDB ID
DrugBank ID
BioGrid ID 109526
GuidetoPHARMACOLOGY ID
PharmGKB ID PA29480
KEGG ID hsa:3293
DIP ID
STRING ID 9606.ENSP00000364412
IntAct ID P37058
DMDM 1169300
BRENDA 1.1.1.51 1.1.1.64
Reactome R-HSA-193048 R-HSA-75876
SignaLink
BioCyc MetaCyc:HS05461-MONOMER
Entrez Gene (Gene ID) 3293
BindingDB P37058

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.928 0.008 0.932 0.003 0.930 0.000 0.930 0.000 0.970 0.000 0.857 0.008 Download
Estate fingerprints 0.839 0.017 0.905 0.009 0.872 0.010 0.867 0.012 0.950 0.000 0.743 0.020 Download
MACCS fingerprints 0.894 0.005 0.914 0.005 0.904 0.005 0.904 0.005 0.953 0.005 0.808 0.008 Download
Daylight fingerprints 0.934 0.011 0.868 0.005 0.901 0.007 0.905 0.005 0.924 0.005 0.806 0.012 Download
ECFP2 fingerprints 0.979 0.009 0.923 0.006 0.951 0.006 0.951 0.006 0.990 0.000 0.901 0.010 Download
ECFP4 fingerprints 0.986 0.005 0.924 0.007 0.955 0.005 0.955 0.005 1.000 0.000 0.907 0.009 Download
ECFP6 fingerprints 0.977 0.005 0.943 0.003 0.960 0.000 0.960 0.000 1.000 0.000 0.919 0.003 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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