Target name

P40238: Thrombopoietin receptor


  Protein function

Receptor for thrombopoietin. May represent a regulatory molecule specific for TPO-R-dependent immune responses.

  Database links

Uniprot primary ID P40238
PDB ID
DrugBank ID DB06210 DB05332
BioGrid ID 110492
GuidetoPHARMACOLOGY ID 1722
PharmGKB ID PA30923
KEGG ID hsa:4352
DIP ID DIP-5730N
STRING ID 9606.ENSP00000361548
IntAct ID P40238
DMDM 730980
BRENDA
Reactome R-HSA-76009
SignaLink P40238
BioCyc
Entrez Gene (Gene ID) 4352
BindingDB P40238

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.885 0.008 0.977 0.000 0.931 0.003 0.929 0.006 0.990 0.000 0.868 0.008 Download
Estate fingerprints 0.927 0.005 0.825 0.008 0.876 0.005 0.883 0.005 0.947 0.005 0.754 0.011 Download
MACCS fingerprints 0.942 0.009 0.882 0.004 0.912 0.004 0.916 0.005 0.960 0.000 0.828 0.009 Download
Daylight fingerprints 0.830 0.000 0.970 0.005 0.900 0.000 0.895 0.005 0.940 0.000 0.815 0.005 Download
ECFP2 fingerprints 1.000 0.000 0.944 0.005 0.972 0.004 0.972 0.004 1.000 0.000 0.944 0.005 Download
ECFP4 fingerprints 1.000 0.000 0.980 0.000 0.990 0.000 0.990 0.000 1.000 0.000 0.989 0.003 Download
ECFP6 fingerprints 0.985 0.005 0.995 0.003 0.990 0.000 0.990 0.000 1.000 0.000 0.981 0.003 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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