Target name

P41143: Delta-type opioid receptor


  Protein function

G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.

  Database links

Uniprot primary ID P41143
PDB ID 4RWA 2IQM 4N6H 1OZC 4RWD
DrugBank ID DB00327 DB00956 DB00611 DB01221 DB00321 DB00813 DB00899
BioGrid ID 111030
GuidetoPHARMACOLOGY ID 317
PharmGKB ID PA31942
KEGG ID hsa:4985
DIP ID
STRING ID 9606.ENSP00000234961
IntAct ID P41143
DMDM 311033488
BRENDA
Reactome R-HSA-418594 R-HSA-375276
SignaLink P41143
BioCyc
Entrez Gene (Gene ID) 4985
BindingDB P41143

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.866 0.005 0.852 0.010 0.859 0.003 0.859 0.003 0.928 0.004 0.717 0.008 Download
Estate fingerprints 0.892 0.004 0.754 0.005 0.823 0.005 0.837 0.005 0.905 0.005 0.653 0.005 Download
MACCS fingerprints 0.852 0.008 0.806 0.005 0.829 0.006 0.832 0.006 0.911 0.003 0.656 0.011 Download
Daylight fingerprints 0.772 0.004 0.902 0.005 0.837 0.005 0.827 0.005 0.869 0.003 0.676 0.007 Download
ECFP2 fingerprints 0.869 0.003 0.903 0.013 0.886 0.007 0.885 0.007 0.950 0.000 0.770 0.013 Download
ECFP4 fingerprints 0.857 0.005 0.935 0.003 0.896 0.005 0.890 0.000 0.950 0.000 0.790 0.000 Download
ECFP6 fingerprints 0.830 0.008 0.944 0.000 0.887 0.005 0.880 0.000 0.940 0.000 0.777 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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