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E-mail: biomed@csu.edu.cn
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Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation in breast cancer cells through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. Has also serine-protein kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), EIF4EBP1 and HRAS.
| Uniprot primary ID | P42336 |
| PDB ID | 4JPS 4WAF 4L1B 4YKN 3ZIM 2RD0 3HIZ 4L23 2ENQ 4TUU 3HHM 4L2Y 4OVU 4TV3 4OVV |
| DrugBank ID | DB00201 |
| BioGrid ID | 111308 |
| GuidetoPHARMACOLOGY ID | 2153 |
| PharmGKB ID | PA33308 |
| KEGG ID | hsa:5290 |
| DIP ID | DIP-42728N |
| STRING ID | 9606.ENSP00000263967 |
| IntAct ID | P42336 |
| DMDM | 126302584 |
| BRENDA | 2.7.1.137 2.7.1.153 |
| Reactome | R-HSA-1660499 R-HSA-4420097 R-HSA-912631 R-HSA-198203 R-HSA-5655332 R-HSA-5654720 R-HSA-114604 R-HSA-389357 R-HSA-2219530 R-HSA-1963642 R-HSA-5654710 R-HSA-5637810 R-HSA-186763 R-HSA-180292 R-HSA-1257604 R-HSA-388841 R-HSA-2029 R-HSA-5654689 R-HSA-2730905 |
| SignaLink | P42336 |
| BioCyc | MetaCyc:HS04527-MONOMER |
| Entrez Gene (Gene ID) | 5290 |
| BindingDB | P42336 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.888 | 0.004 | 0.872 | 0.003 | 0.880 | 0.000 | 0.880 | 0.000 | 0.940 | 0.000 | 0.760 | 0.000 | Download |
| Estate fingerprints | 0.820 | 0.000 | 0.734 | 0.000 | 0.777 | 0.005 | 0.788 | 0.004 | 0.850 | 0.000 | 0.552 | 0.004 | Download |
| MACCS fingerprints | 0.851 | 0.003 | 0.789 | 0.000 | 0.820 | 0.000 | 0.830 | 0.000 | 0.900 | 0.000 | 0.643 | 0.005 | Download |
| Daylight fingerprints | 0.860 | 0.000 | 0.772 | 0.000 | 0.816 | 0.005 | 0.821 | 0.003 | 0.870 | 0.000 | 0.633 | 0.005 | Download |
| ECFP2 fingerprints | 0.971 | 0.003 | 0.893 | 0.005 | 0.932 | 0.004 | 0.940 | 0.000 | 0.990 | 0.000 | 0.870 | 0.000 | Download |
| ECFP4 fingerprints | 0.950 | 0.000 | 0.970 | 0.000 | 0.960 | 0.000 | 0.960 | 0.000 | 0.990 | 0.000 | 0.920 | 0.000 | Download |
| ECFP6 fingerprints | 0.926 | 0.005 | 0.990 | 0.005 | 0.958 | 0.004 | 0.951 | 0.003 | 0.990 | 0.000 | 0.910 | 0.000 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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