Target name

P43119: Prostacyclin receptor


  Protein function

Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.

  Database links

Uniprot primary ID P43119
PDB ID
DrugBank ID DB01160 DB01088 DB01240 DB00374
BioGrid ID 111711
GuidetoPHARMACOLOGY ID 345
PharmGKB ID PA291
KEGG ID hsa:5739
DIP ID
STRING ID 9606.ENSP00000291294
IntAct ID
DMDM 1172500
BRENDA
Reactome R-HSA-391908 R-HSA-418555 R-HSA-392851
SignaLink
BioCyc
Entrez Gene (Gene ID) 5739
BindingDB P43119

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.871 0.006 0.907 0.005 0.889 0.003 0.885 0.007 0.949 0.003 0.775 0.011 Download
Estate fingerprints 0.848 0.006 0.824 0.008 0.836 0.005 0.837 0.005 0.899 0.003 0.670 0.008 Download
MACCS fingerprints 0.818 0.008 0.830 0.005 0.824 0.005 0.823 0.005 0.909 0.003 0.646 0.010 Download
Daylight fingerprints 0.684 0.022 0.952 0.005 0.818 0.011 0.791 0.018 0.937 0.005 0.663 0.022 Download
ECFP2 fingerprints 0.924 0.010 0.948 0.004 0.936 0.005 0.936 0.005 0.980 0.000 0.871 0.007 Download
ECFP4 fingerprints 0.920 0.012 0.980 0.004 0.950 0.005 0.949 0.006 0.988 0.004 0.902 0.009 Download
ECFP6 fingerprints 0.870 0.012 0.996 0.000 0.933 0.007 0.930 0.007 0.979 0.003 0.876 0.013 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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