This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).
| Uniprot primary ID | P43140 |
| PDB ID | 2F75 |
| DrugBank ID | |
| BioGrid ID | |
| GuidetoPHARMACOLOGY ID | 22 |
| PharmGKB ID | |
| KEGG ID | rno:29412 |
| DIP ID | |
| STRING ID | 10116.ENSRNOP00000012736 |
| IntAct ID | |
| DMDM | |
| BRENDA | |
| Reactome | R-RNO-390696 R-RNO-416482 R-RNO-416476 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 29412 |
| BindingDB | P43140 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.846 | 0.005 | 0.822 | 0.005 | 0.834 | 0.005 | 0.837 | 0.005 | 0.910 | 0.000 | 0.669 | 0.003 | Download |
| Estate fingerprints | 0.801 | 0.007 | 0.775 | 0.007 | 0.788 | 0.004 | 0.790 | 0.000 | 0.851 | 0.003 | 0.574 | 0.005 | Download |
| MACCS fingerprints | 0.879 | 0.003 | 0.691 | 0.003 | 0.785 | 0.005 | 0.802 | 0.004 | 0.880 | 0.000 | 0.579 | 0.003 | Download |
| Daylight fingerprints | 0.769 | 0.009 | 0.787 | 0.003 | 0.778 | 0.004 | 0.776 | 0.005 | 0.845 | 0.005 | 0.557 | 0.007 | Download |
| ECFP2 fingerprints | 0.886 | 0.007 | 0.882 | 0.006 | 0.884 | 0.005 | 0.884 | 0.005 | 0.950 | 0.000 | 0.771 | 0.007 | Download |
| ECFP4 fingerprints | 0.880 | 0.005 | 0.940 | 0.000 | 0.910 | 0.000 | 0.909 | 0.003 | 0.970 | 0.000 | 0.822 | 0.004 | Download |
| ECFP6 fingerprints | 0.824 | 0.007 | 0.970 | 0.005 | 0.897 | 0.005 | 0.888 | 0.004 | 0.964 | 0.005 | 0.799 | 0.006 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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