Target name

P43140: Alpha-1A adrenergic receptor


  Protein function

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).

  Database links

Uniprot primary ID P43140
PDB ID 2F75
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 22
PharmGKB ID
KEGG ID rno:29412
DIP ID
STRING ID 10116.ENSRNOP00000012736
IntAct ID
DMDM
BRENDA
Reactome R-RNO-390696 R-RNO-416482 R-RNO-416476
SignaLink
BioCyc
Entrez Gene (Gene ID) 29412
BindingDB P43140

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.846 0.005 0.822 0.005 0.834 0.005 0.837 0.005 0.910 0.000 0.669 0.003 Download
Estate fingerprints 0.801 0.007 0.775 0.007 0.788 0.004 0.790 0.000 0.851 0.003 0.574 0.005 Download
MACCS fingerprints 0.879 0.003 0.691 0.003 0.785 0.005 0.802 0.004 0.880 0.000 0.579 0.003 Download
Daylight fingerprints 0.769 0.009 0.787 0.003 0.778 0.004 0.776 0.005 0.845 0.005 0.557 0.007 Download
ECFP2 fingerprints 0.886 0.007 0.882 0.006 0.884 0.005 0.884 0.005 0.950 0.000 0.771 0.007 Download
ECFP4 fingerprints 0.880 0.005 0.940 0.000 0.910 0.000 0.909 0.003 0.970 0.000 0.822 0.004 Download
ECFP6 fingerprints 0.824 0.007 0.970 0.005 0.897 0.005 0.888 0.004 0.964 0.005 0.799 0.006 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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