Target name

P49137: MAP kinase-activated protein kinase 2


  Protein function

Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, ELAVL1, HNRNPA0, HSF1, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA0, PABPC1 and TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA0 and PARN, leading to stabilize GADD45A mRNA. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3.

  Database links

Uniprot primary ID P49137
PDB ID 3FYJ 3FYK 2JBP 2ONL 4TYH 3KA0 2P3G 3KC3 3A2C 3M42 3GOK 2OZA 1KWP 3R30 2PZY 3KGA 2JBO 2OKR 3WI6 1NY3 1NXK 3R2Y 3FPM 3M2W 3R2B
DrugBank ID
BioGrid ID 114683
GuidetoPHARMACOLOGY ID 2094
PharmGKB ID PA30631
KEGG ID hsa:9261
DIP ID DIP-35671N
STRING ID 9606.ENSP00000356070
IntAct ID P49137
DMDM 1346538
BRENDA 2.7.11.1
Reactome R-HSA-4420097 R-HSA-450302 R-HSA-2559580 R-HSA-171007 R-HSA-450385 R-HSA-199920 R-HSA-450513 R-HSA-3371453 R-HSA-2142691
SignaLink P49137
BioCyc MetaCyc:HS08751-MONOMER
Entrez Gene (Gene ID) 9261
BindingDB P49137

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.831 0.006 0.907 0.003 0.869 0.003 0.865 0.005 0.950 0.000 0.742 0.006 Download
Estate fingerprints 0.822 0.006 0.750 0.005 0.786 0.005 0.793 0.005 0.870 0.000 0.573 0.007 Download
MACCS fingerprints 0.934 0.005 0.780 0.000 0.857 0.005 0.868 0.004 0.931 0.003 0.722 0.006 Download
Daylight fingerprints 0.744 0.005 0.756 0.000 0.750 0.000 0.750 0.000 0.800 0.000 0.500 0.005 Download
ECFP2 fingerprints 0.947 0.005 0.891 0.005 0.919 0.003 0.920 0.000 0.978 0.004 0.837 0.005 Download
ECFP4 fingerprints 0.930 0.000 0.970 0.005 0.950 0.000 0.950 0.000 0.980 0.000 0.899 0.006 Download
ECFP6 fingerprints 0.902 0.004 0.996 0.003 0.949 0.003 0.942 0.004 0.980 0.000 0.895 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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