Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Binds to CCL21. Probably promotes cell chemotaxis response.
| Uniprot primary ID | P49682 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | 109094 |
| GuidetoPHARMACOLOGY ID | 70 |
| PharmGKB ID | PA35049 |
| KEGG ID | hsa:2833 |
| DIP ID | DIP-5891N |
| STRING ID | 9606.ENSP00000362795 |
| IntAct ID | |
| DMDM | 2829400 |
| BRENDA | |
| Reactome | R-HSA-418594 R-HSA-380108 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 2833 |
| BindingDB | P49682 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.861 | 0.003 | 0.933 | 0.005 | 0.897 | 0.005 | 0.893 | 0.005 | 0.970 | 0.000 | 0.796 | 0.005 | Download |
| Estate fingerprints | 0.886 | 0.005 | 0.794 | 0.003 | 0.840 | 0.000 | 0.850 | 0.000 | 0.910 | 0.000 | 0.687 | 0.005 | Download |
| MACCS fingerprints | 0.917 | 0.005 | 0.803 | 0.000 | 0.860 | 0.000 | 0.870 | 0.000 | 0.940 | 0.000 | 0.729 | 0.003 | Download |
| Daylight fingerprints | 0.771 | 0.006 | 0.829 | 0.005 | 0.800 | 0.000 | 0.797 | 0.005 | 0.850 | 0.000 | 0.603 | 0.007 | Download |
| ECFP2 fingerprints | 0.990 | 0.000 | 0.950 | 0.000 | 0.970 | 0.000 | 0.970 | 0.000 | 1.000 | 0.000 | 0.939 | 0.003 | Download |
| ECFP4 fingerprints | 0.990 | 0.000 | 0.990 | 0.005 | 0.990 | 0.000 | 0.990 | 0.000 | 1.000 | 0.000 | 0.984 | 0.005 | Download |
| ECFP6 fingerprints | 0.980 | 0.000 | 1.000 | 0.005 | 0.990 | 0.000 | 0.990 | 0.000 | 1.000 | 0.000 | 0.978 | 0.004 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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