Target name

P49682: C-X-C chemokine receptor type 3


  Protein function

Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Binds to CCL21. Probably promotes cell chemotaxis response.

  Database links

Uniprot primary ID P49682
PDB ID
DrugBank ID
BioGrid ID 109094
GuidetoPHARMACOLOGY ID 70
PharmGKB ID PA35049
KEGG ID hsa:2833
DIP ID DIP-5891N
STRING ID 9606.ENSP00000362795
IntAct ID
DMDM 2829400
BRENDA
Reactome R-HSA-418594 R-HSA-380108
SignaLink
BioCyc
Entrez Gene (Gene ID) 2833
BindingDB P49682

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.861 0.003 0.933 0.005 0.897 0.005 0.893 0.005 0.970 0.000 0.796 0.005 Download
Estate fingerprints 0.886 0.005 0.794 0.003 0.840 0.000 0.850 0.000 0.910 0.000 0.687 0.005 Download
MACCS fingerprints 0.917 0.005 0.803 0.000 0.860 0.000 0.870 0.000 0.940 0.000 0.729 0.003 Download
Daylight fingerprints 0.771 0.006 0.829 0.005 0.800 0.000 0.797 0.005 0.850 0.000 0.603 0.007 Download
ECFP2 fingerprints 0.990 0.000 0.950 0.000 0.970 0.000 0.970 0.000 1.000 0.000 0.939 0.003 Download
ECFP4 fingerprints 0.990 0.000 0.990 0.005 0.990 0.000 0.990 0.000 1.000 0.000 0.984 0.005 Download
ECFP6 fingerprints 0.980 0.000 1.000 0.005 0.990 0.000 0.990 0.000 1.000 0.000 0.978 0.004 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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