This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling (PubMed:23027611).
| Uniprot primary ID | P50406 |
| PDB ID | |
| DrugBank ID | DB00458 DB01142 DB00477 DB00334 DB04946 DB00246 DB01238 |
| BioGrid ID | 109594 |
| GuidetoPHARMACOLOGY ID | 11 |
| PharmGKB ID | PA29560 |
| KEGG ID | hsa:3362 |
| DIP ID | |
| STRING ID | 9606.ENSP00000289753 |
| IntAct ID | P50406 |
| DMDM | 1703010 |
| BRENDA | |
| Reactome | R-HSA-390666 R-HSA-418555 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 3362 |
| BindingDB | P50406 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.826 | 0.005 | 0.954 | 0.000 | 0.890 | 0.000 | 0.880 | 0.000 | 0.950 | 0.000 | 0.780 | 0.000 | Download |
| Estate fingerprints | 0.810 | 0.000 | 0.870 | 0.000 | 0.840 | 0.000 | 0.832 | 0.004 | 0.920 | 0.000 | 0.679 | 0.003 | Download |
| MACCS fingerprints | 0.780 | 0.000 | 0.880 | 0.000 | 0.830 | 0.000 | 0.820 | 0.000 | 0.920 | 0.000 | 0.650 | 0.000 | Download |
| Daylight fingerprints | 0.752 | 0.004 | 0.870 | 0.000 | 0.811 | 0.003 | 0.800 | 0.000 | 0.830 | 0.000 | 0.631 | 0.003 | Download |
| ECFP2 fingerprints | 0.900 | 0.000 | 0.940 | 0.000 | 0.920 | 0.000 | 0.920 | 0.000 | 0.980 | 0.000 | 0.850 | 0.000 | Download |
| ECFP4 fingerprints | 0.899 | 0.003 | 0.965 | 0.000 | 0.932 | 0.004 | 0.930 | 0.000 | 0.980 | 0.000 | 0.870 | 0.000 | Download |
| ECFP6 fingerprints | 0.880 | 0.000 | 0.980 | 0.000 | 0.930 | 0.000 | 0.930 | 0.000 | 0.980 | 0.000 | 0.869 | 0.003 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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