Target name

P50406: 5-hydroxytryptamine receptor 6


  Protein function

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling (PubMed:23027611).

  Database links

Uniprot primary ID P50406
PDB ID
DrugBank ID DB00458 DB01142 DB00477 DB00334 DB04946 DB00246 DB01238
BioGrid ID 109594
GuidetoPHARMACOLOGY ID 11
PharmGKB ID PA29560
KEGG ID hsa:3362
DIP ID
STRING ID 9606.ENSP00000289753
IntAct ID P50406
DMDM 1703010
BRENDA
Reactome R-HSA-390666 R-HSA-418555
SignaLink
BioCyc
Entrez Gene (Gene ID) 3362
BindingDB P50406

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.826 0.005 0.954 0.000 0.890 0.000 0.880 0.000 0.950 0.000 0.780 0.000 Download
Estate fingerprints 0.810 0.000 0.870 0.000 0.840 0.000 0.832 0.004 0.920 0.000 0.679 0.003 Download
MACCS fingerprints 0.780 0.000 0.880 0.000 0.830 0.000 0.820 0.000 0.920 0.000 0.650 0.000 Download
Daylight fingerprints 0.752 0.004 0.870 0.000 0.811 0.003 0.800 0.000 0.830 0.000 0.631 0.003 Download
ECFP2 fingerprints 0.900 0.000 0.940 0.000 0.920 0.000 0.920 0.000 0.980 0.000 0.850 0.000 Download
ECFP4 fingerprints 0.899 0.003 0.965 0.000 0.932 0.004 0.930 0.000 0.980 0.000 0.870 0.000 Download
ECFP6 fingerprints 0.880 0.000 0.980 0.000 0.930 0.000 0.930 0.000 0.980 0.000 0.869 0.003 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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