Target name

P50613: Cyclin-dependent kinase 7


  Protein function

Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering dissociation from DNA. Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition.

  Database links

Uniprot primary ID P50613
PDB ID 1LG3 1PA8 2HIC 1UA2
DrugBank ID
BioGrid ID 107457
GuidetoPHARMACOLOGY ID 1979
PharmGKB ID PA26314
KEGG ID hsa:1022
DIP ID DIP-5995N
STRING ID 9606.ENSP00000256443
IntAct ID P50613
DMDM 1705722
BRENDA 2.7.11.22 2.7.11.23
Reactome R-HSA-167172 R-HSA-69231 R-HSA-167152 R-HSA-427413 R-HSA-72086 R-HSA-110304 R-HSA-167158 R-HSA-110302 R-HSA- R-HSA-69273 R-HSA-73935 R-HSA-73772 R-HSA-73762 R-HSA-73777 R-HSA-73776 R-HSA-73779 R-HSA-73941 R-HSA-167161 R-HSA-167160 R-HSA-73863 R-HSA-674695
SignaLink P50613
BioCyc
Entrez Gene (Gene ID) 1022
BindingDB P50613

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.680 0.013 0.924 0.005 0.802 0.009 0.777 0.011 0.891 0.003 0.622 0.015 Download
Estate fingerprints 0.770 0.011 0.752 0.014 0.761 0.009 0.764 0.011 0.838 0.006 0.522 0.018 Download
MACCS fingerprints 0.818 0.013 0.756 0.012 0.787 0.009 0.796 0.010 0.867 0.005 0.580 0.021 Download
Daylight fingerprints 0.652 0.013 0.880 0.012 0.766 0.008 0.736 0.010 0.857 0.007 0.551 0.017 Download
ECFP2 fingerprints 0.834 0.015 0.818 0.010 0.826 0.007 0.829 0.007 0.918 0.004 0.657 0.015 Download
ECFP4 fingerprints 0.765 0.008 0.913 0.005 0.839 0.006 0.826 0.007 0.931 0.003 0.683 0.011 Download
ECFP6 fingerprints 0.705 0.010 0.937 0.008 0.821 0.006 0.801 0.006 0.913 0.005 0.663 0.011 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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