Details-Calcnet-TargetNet

Target name

P51452: Dual specificity protein phosphatase 3

Protein function

Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2.

Database links

Uniprot primary ID	P51452
PDB ID	1J4X 3F81 1VHR
DrugBank ID
BioGrid ID	108178
GuidetoPHARMACOLOGY ID
PharmGKB ID	PA27526
KEGG ID	hsa:1845
DIP ID
STRING ID	9606.ENSP00000226004
IntAct ID	P51452
DMDM	1718191
BRENDA
Reactome	R-HSA-202670
SignaLink	P51452
BioCyc
Entrez Gene (Gene ID)	1845
BindingDB	P51452

Model Performance Metrics

Fingerprint type	Sensitivity	SEN_std	Specificity	SPE_std	Accuracy	ACC_std	F1-score	F1-score_std	AUC	AUC_std	MCC	MCC_std	Download model
FP2 fingerprints	0.742	0.006	0.820	0.008	0.781	0.007	0.774	0.007	0.879	0.003	0.570	0.012	Download
Estate fingerprints	0.746	0.005	0.792	0.005	0.769	0.003	0.765	0.005	0.856	0.005	0.543	0.007	Download
MACCS fingerprints	0.722	0.004	0.750	0.007	0.736	0.005	0.733	0.005	0.830	0.000	0.474	0.008	Download
Daylight fingerprints	0.633	0.008	0.751	0.006	0.692	0.006	0.673	0.007	0.748	0.004	0.388	0.010	Download
ECFP2 fingerprints	0.868	0.006	0.816	0.005	0.842	0.004	0.844	0.005	0.915	0.005	0.684	0.005	Download
ECFP4 fingerprints	0.875	0.008	0.819	0.005	0.847	0.005	0.852	0.006	0.922	0.004	0.697	0.009	Download
ECFP6 fingerprints	0.856	0.008	0.818	0.007	0.837	0.005	0.838	0.006	0.913	0.005	0.672	0.012	Download

Download datasets

Positive dataset

Negative dataset