Target name

P51452: Dual specificity protein phosphatase 3


  Protein function

Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2.

  Database links

Uniprot primary ID P51452
PDB ID 1J4X 3F81 1VHR
DrugBank ID
BioGrid ID 108178
GuidetoPHARMACOLOGY ID
PharmGKB ID PA27526
KEGG ID hsa:1845
DIP ID
STRING ID 9606.ENSP00000226004
IntAct ID P51452
DMDM 1718191
BRENDA
Reactome R-HSA-202670
SignaLink P51452
BioCyc
Entrez Gene (Gene ID) 1845
BindingDB P51452

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.742 0.006 0.820 0.008 0.781 0.007 0.774 0.007 0.879 0.003 0.570 0.012 Download
Estate fingerprints 0.746 0.005 0.792 0.005 0.769 0.003 0.765 0.005 0.856 0.005 0.543 0.007 Download
MACCS fingerprints 0.722 0.004 0.750 0.007 0.736 0.005 0.733 0.005 0.830 0.000 0.474 0.008 Download
Daylight fingerprints 0.633 0.008 0.751 0.006 0.692 0.006 0.673 0.007 0.748 0.004 0.388 0.010 Download
ECFP2 fingerprints 0.868 0.006 0.816 0.005 0.842 0.004 0.844 0.005 0.915 0.005 0.684 0.005 Download
ECFP4 fingerprints 0.875 0.008 0.819 0.005 0.847 0.005 0.852 0.006 0.922 0.004 0.697 0.009 Download
ECFP6 fingerprints 0.856 0.008 0.818 0.007 0.837 0.005 0.838 0.006 0.913 0.005 0.672 0.012 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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