Details-Calcnet-TargetNet

Target name

P51679: C-C chemokine receptor type 4

Protein function

High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.

Database links

Uniprot primary ID	P51679
PDB ID
DrugBank ID
BioGrid ID	107638
GuidetoPHARMACOLOGY ID	61
PharmGKB ID	PA26169
KEGG ID	hsa:1233
DIP ID	DIP-5848N
STRING ID	9606.ENSP00000332659
IntAct ID	P51679
DMDM	1705894
BRENDA
Reactome	R-HSA-418594 R-HSA-380108
SignaLink
BioCyc
Entrez Gene (Gene ID)	1233
BindingDB	P51679

Model Performance Metrics

Fingerprint type	Sensitivity	SEN_std	Specificity	SPE_std	Accuracy	ACC_std	F1-score	F1-score_std	AUC	AUC_std	MCC	MCC_std	Download model
FP2 fingerprints	0.871	0.006	0.957	0.005	0.914	0.005	0.909	0.003	0.970	0.000	0.829	0.003	Download
Estate fingerprints	0.844	0.008	0.790	0.010	0.817	0.007	0.822	0.004	0.900	0.005	0.634	0.011	Download
MACCS fingerprints	0.867	0.007	0.707	0.007	0.787	0.005	0.801	0.006	0.869	0.003	0.577	0.011	Download
Daylight fingerprints	0.754	0.007	0.980	0.003	0.867	0.005	0.850	0.000	0.925	0.005	0.754	0.005	Download
ECFP2 fingerprints	0.976	0.005	0.928	0.010	0.952	0.004	0.952	0.004	0.990	0.000	0.903	0.009	Download
ECFP4 fingerprints	0.956	0.005	0.968	0.000	0.962	0.004	0.962	0.004	0.988	0.004	0.926	0.007	Download
ECFP6 fingerprints	0.928	0.008	0.984	0.003	0.956	0.005	0.956	0.005	0.989	0.003	0.916	0.007	Download

Download datasets

Positive dataset

Negative dataset