Target name

P51679: C-C chemokine receptor type 4


  Protein function

High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.

  Database links

Uniprot primary ID P51679
PDB ID
DrugBank ID
BioGrid ID 107638
GuidetoPHARMACOLOGY ID 61
PharmGKB ID PA26169
KEGG ID hsa:1233
DIP ID DIP-5848N
STRING ID 9606.ENSP00000332659
IntAct ID P51679
DMDM 1705894
BRENDA
Reactome R-HSA-418594 R-HSA-380108
SignaLink
BioCyc
Entrez Gene (Gene ID) 1233
BindingDB P51679

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.871 0.006 0.957 0.005 0.914 0.005 0.909 0.003 0.970 0.000 0.829 0.003 Download
Estate fingerprints 0.844 0.008 0.790 0.010 0.817 0.007 0.822 0.004 0.900 0.005 0.634 0.011 Download
MACCS fingerprints 0.867 0.007 0.707 0.007 0.787 0.005 0.801 0.006 0.869 0.003 0.577 0.011 Download
Daylight fingerprints 0.754 0.007 0.980 0.003 0.867 0.005 0.850 0.000 0.925 0.005 0.754 0.005 Download
ECFP2 fingerprints 0.976 0.005 0.928 0.010 0.952 0.004 0.952 0.004 0.990 0.000 0.903 0.009 Download
ECFP4 fingerprints 0.956 0.005 0.968 0.000 0.962 0.004 0.962 0.004 0.988 0.004 0.926 0.007 Download
ECFP6 fingerprints 0.928 0.008 0.984 0.003 0.956 0.005 0.956 0.005 0.989 0.003 0.916 0.007 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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