Target name

P54760: Ephrin type-B receptor 4


  Protein function

Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis.

  Database links

Uniprot primary ID P54760
PDB ID 2HLE 2E7H 2VWV 2VWY 2QKQ 2VWZ 4AW5 2VWX 2XVD 2YN8 2VWW 3ZEW 4BB4 2VWU 2X9F 2VX0 2VX1 2BBA
DrugBank ID
BioGrid ID 108364
GuidetoPHARMACOLOGY ID 1833
PharmGKB ID PA27827
KEGG ID hsa:2050
DIP ID
STRING ID 9606.ENSP00000350896
IntAct ID P54760
DMDM 19860819
BRENDA 2.7.10.1
Reactome R-HSA-3928665 R-HSA-3928664 R-HSA-2682334 R-HSA-3928662
SignaLink P54760
BioCyc
Entrez Gene (Gene ID) 2050
BindingDB P54760

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.850 0.000 0.896 0.006 0.873 0.005 0.872 0.004 0.923 0.005 0.751 0.006 Download
Estate fingerprints 0.861 0.006 0.713 0.006 0.787 0.005 0.802 0.004 0.849 0.003 0.580 0.007 Download
MACCS fingerprints 0.861 0.003 0.799 0.005 0.830 0.000 0.834 0.005 0.909 0.003 0.657 0.007 Download
Daylight fingerprints 0.857 0.005 0.919 0.007 0.888 0.004 0.884 0.007 0.930 0.000 0.774 0.012 Download
ECFP2 fingerprints 0.903 0.005 0.845 0.007 0.874 0.005 0.881 0.003 0.940 0.000 0.754 0.007 Download
ECFP4 fingerprints 0.846 0.005 0.950 0.006 0.898 0.006 0.894 0.005 0.948 0.004 0.802 0.010 Download
ECFP6 fingerprints 0.811 0.003 0.975 0.005 0.893 0.005 0.886 0.005 0.940 0.000 0.799 0.007 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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