TargetNet
  Target name

P55210: Caspase-7

  Protein function

Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.

  Database links
Uniprot primary ID P55210
PDB ID 1I51 2QLJ 1KMC 2QLF 2QLB 1SHL 3IBC 3H1P 3IBF 4FDL 4JR1 1SHJ 1F1J 1I4O 3R5K 1MIA 1GQF 4JR2 4FEA 1K86 4JJ8 3EDR 4HQR 1K88 4HQ0 2QL9 4LSZ 2QL7 2QL5 4JB8
DrugBank ID
BioGrid ID 107290
GuidetoPHARMACOLOGY ID 1623
PharmGKB ID PA26091
KEGG ID hsa:840
DIP ID DIP-29973N
STRING ID 9606.ENSP00000358327
IntAct ID P55210
DMDM 1730092
BRENDA 3.4.22.60
Reactome R-HSA-111465 R-HSA-111464 R-HSA-111459 R-HSA-111463 R-HSA-264870
SignaLink
BioCyc
Entrez Gene (Gene ID) 840
BindingDB P55210
  Model Performance Metrics
Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.904 0.005 0.986 0.003 0.945 0.005 0.943 0.005 0.990 0.000 0.894 0.005 Download
Estate fingerprints 0.881 0.009 0.781 0.005 0.831 0.006 0.837 0.005 0.918 0.004 0.667 0.009 Download
MACCS fingerprints 0.815 0.008 0.909 0.000 0.862 0.004 0.857 0.005 0.950 0.000 0.731 0.006 Download
Daylight fingerprints 0.763 0.005 0.983 0.000 0.873 0.005 0.859 0.003 0.962 0.004 0.769 0.003 Download
ECFP2 fingerprints 0.959 0.003 0.983 0.003 0.971 0.003 0.971 0.003 0.990 0.000 0.950 0.000 Download
ECFP4 fingerprints 0.953 0.005 1.000 0.000 0.977 0.005 0.977 0.005 0.990 0.000 0.953 0.005 Download
ECFP6 fingerprints 0.937 0.005 1.000 0.000 0.970 0.000 0.970 0.000 0.990 0.000 0.940 0.000 Download
  Download datasets
Positive dataset Negative dataset

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 E-mail: biomed@csu.edu.cn