Details-Calcnet-TargetNet

Target name

P56524: Histone deacetylase 4

Protein function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.

Database links

Uniprot primary ID	P56524
PDB ID	2VQW 2VQV 2VQQ 2O94 2H8N 4CBT 3V31 4CBY 3UXG 2VQO 2VQJ 3UZD 2VQM
DrugBank ID
BioGrid ID	115106
GuidetoPHARMACOLOGY ID	2659
PharmGKB ID	PA29229
KEGG ID	hsa:9759
DIP ID	DIP-34565N
STRING ID	9606.ENSP00000264606
IntAct ID	P56524
DMDM	259016348
BRENDA	3.5.1.98
Reactome	R-HSA-2122947 R-HSA-2894862 R-HSA-2644606
SignaLink
BioCyc
Entrez Gene (Gene ID)	9759
BindingDB	P56524

Model Performance Metrics

Fingerprint type	Sensitivity	SEN_std	Specificity	SPE_std	Accuracy	ACC_std	F1-score	F1-score_std	AUC	AUC_std	MCC	MCC_std	Download model
FP2 fingerprints	0.844	0.012	0.892	0.005	0.868	0.008	0.864	0.008	0.947	0.005	0.738	0.014	Download
Estate fingerprints	0.859	0.021	0.753	0.013	0.806	0.011	0.816	0.011	0.901	0.003	0.616	0.022	Download
MACCS fingerprints	0.907	0.008	0.915	0.004	0.911	0.006	0.910	0.007	0.960	0.000	0.820	0.011	Download
Daylight fingerprints	0.778	0.009	0.854	0.005	0.816	0.005	0.809	0.006	0.851	0.003	0.636	0.008	Download
ECFP2 fingerprints	0.941	0.003	0.921	0.003	0.931	0.003	0.931	0.003	0.973	0.005	0.865	0.005	Download
ECFP4 fingerprints	0.950	0.007	0.934	0.000	0.942	0.004	0.942	0.004	0.980	0.000	0.885	0.007	Download
ECFP6 fingerprints	0.929	0.009	0.937	0.006	0.933	0.005	0.933	0.005	0.980	0.000	0.864	0.007	Download

Download datasets

Positive dataset

Negative dataset