Target name

P56524: Histone deacetylase 4


  Protein function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.

  Database links

Uniprot primary ID P56524
PDB ID 2VQW 2VQV 2VQQ 2O94 2H8N 4CBT 3V31 4CBY 3UXG 2VQO 2VQJ 3UZD 2VQM
DrugBank ID
BioGrid ID 115106
GuidetoPHARMACOLOGY ID 2659
PharmGKB ID PA29229
KEGG ID hsa:9759
DIP ID DIP-34565N
STRING ID 9606.ENSP00000264606
IntAct ID P56524
DMDM 259016348
BRENDA 3.5.1.98
Reactome R-HSA-2122947 R-HSA-2894862 R-HSA-2644606
SignaLink
BioCyc
Entrez Gene (Gene ID) 9759
BindingDB P56524

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.844 0.012 0.892 0.005 0.868 0.008 0.864 0.008 0.947 0.005 0.738 0.014 Download
Estate fingerprints 0.859 0.021 0.753 0.013 0.806 0.011 0.816 0.011 0.901 0.003 0.616 0.022 Download
MACCS fingerprints 0.907 0.008 0.915 0.004 0.911 0.006 0.910 0.007 0.960 0.000 0.820 0.011 Download
Daylight fingerprints 0.778 0.009 0.854 0.005 0.816 0.005 0.809 0.006 0.851 0.003 0.636 0.008 Download
ECFP2 fingerprints 0.941 0.003 0.921 0.003 0.931 0.003 0.931 0.003 0.973 0.005 0.865 0.005 Download
ECFP4 fingerprints 0.950 0.007 0.934 0.000 0.942 0.004 0.942 0.004 0.980 0.000 0.885 0.007 Download
ECFP6 fingerprints 0.929 0.009 0.937 0.006 0.933 0.005 0.933 0.005 0.980 0.000 0.864 0.007 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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