Target name

P56658: Adenosine deaminase


  Protein function

Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (By similarity).

  Database links

Uniprot primary ID P56658
PDB ID 1WXY 1WXZ 1NDV 1NDY 1NDZ 1NDW 2E1W 1UML 1V7A 1QXL 1VFL 1KRM 1O5R 1W1I 2BGN 2Z7G 1V79
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID bta:280712
DIP ID
STRING ID 9913.ENSBTAP00000006947
IntAct ID P56658
DMDM
BRENDA 3.5.4.4
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 280712
BindingDB P56658

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.746 0.016 1.000 0.000 0.873 0.008 0.854 0.011 0.999 0.003 0.770 0.013 Download
Estate fingerprints 0.939 0.003 0.961 0.005 0.950 0.000 0.950 0.000 0.990 0.000 0.901 0.003 Download
MACCS fingerprints 0.922 0.004 0.978 0.004 0.950 0.000 0.950 0.000 0.990 0.000 0.903 0.005 Download
Daylight fingerprints 0.818 0.008 0.994 0.000 0.906 0.005 0.898 0.008 0.983 0.005 0.826 0.008 Download
ECFP2 fingerprints 0.970 0.000 0.990 0.000 0.980 0.000 0.980 0.000 1.000 0.000 0.970 0.000 Download
ECFP4 fingerprints 0.970 0.005 0.992 0.000 0.981 0.003 0.980 0.000 1.000 0.000 0.965 0.005 Download
ECFP6 fingerprints 0.951 0.006 0.993 0.000 0.972 0.004 0.970 0.000 1.000 0.000 0.949 0.003 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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