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E-mail: biomed@csu.edu.cn
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Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
| Uniprot primary ID | P62942 |
| PDB ID | 1QPF 2FAP 3H9R 1NSG 1EYM 1D6O 1F40 1D7H 1A7X 2FKE 4N19 1FKD 1J4R 1FAP 1J4I 1J4H 3MDY 1FKR 3FAP 1B6C 2PPN 1QPL 1FKS 1FKT 1BL4 2PPO 1FKH 1FKI 1FKJ 2DG4 1D7J 1FKB 1D7I 2RSE 1FKF 1FKG 4ODR 4ODQ 4ODP 2DG3 4IPX 1BKF 2PPP 2DG9 4DH0 4FAP |
| DrugBank ID | DB00337 DB00864 DB00877 |
| BioGrid ID | 108570 |
| GuidetoPHARMACOLOGY ID | 2609 |
| PharmGKB ID | PA28153 |
| KEGG ID | hsa:2280 |
| DIP ID | DIP-29710N |
| STRING ID | 9606.ENSP00000371138 |
| IntAct ID | P62942 |
| DMDM | |
| BRENDA | 5.2.1.8 |
| Reactome | R-HSA-2173791 R-HSA-3656532 R-HSA-3656535 R-HSA-3645790 R-HSA-2173789 |
| SignaLink | P62942 |
| BioCyc | |
| Entrez Gene (Gene ID) | 2280 |
| BindingDB | P62942 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.953 | 0.005 | 0.981 | 0.000 | 0.967 | 0.005 | 0.967 | 0.005 | 0.990 | 0.000 | 0.934 | 0.005 | Download |
| Estate fingerprints | 0.970 | 0.000 | 0.882 | 0.007 | 0.926 | 0.005 | 0.929 | 0.003 | 0.980 | 0.000 | 0.856 | 0.005 | Download |
| MACCS fingerprints | 0.940 | 0.000 | 0.948 | 0.003 | 0.944 | 0.005 | 0.944 | 0.005 | 0.990 | 0.000 | 0.891 | 0.006 | Download |
| Daylight fingerprints | 0.883 | 0.005 | 0.975 | 0.005 | 0.929 | 0.003 | 0.926 | 0.005 | 0.962 | 0.004 | 0.860 | 0.005 | Download |
| ECFP2 fingerprints | 0.986 | 0.005 | 0.994 | 0.004 | 0.990 | 0.000 | 0.990 | 0.000 | 1.000 | 0.000 | 0.980 | 0.000 | Download |
| ECFP4 fingerprints | 0.980 | 0.000 | 1.000 | 0.000 | 0.990 | 0.000 | 0.990 | 0.000 | 1.000 | 0.000 | 0.980 | 0.000 | Download |
| ECFP6 fingerprints | 0.974 | 0.005 | 1.000 | 0.000 | 0.989 | 0.003 | 0.989 | 0.003 | 1.000 | 0.000 | 0.974 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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