Target name

P62942: Peptidyl-prolyl cis-trans isomerase FKBP1A


  Protein function

Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

  Database links

Uniprot primary ID P62942
PDB ID 1QPF 2FAP 3H9R 1NSG 1EYM 1D6O 1F40 1D7H 1A7X 2FKE 4N19 1FKD 1J4R 1FAP 1J4I 1J4H 3MDY 1FKR 3FAP 1B6C 2PPN 1QPL 1FKS 1FKT 1BL4 2PPO 1FKH 1FKI 1FKJ 2DG4 1D7J 1FKB 1D7I 2RSE 1FKF 1FKG 4ODR 4ODQ 4ODP 2DG3 4IPX 1BKF 2PPP 2DG9 4DH0 4FAP
DrugBank ID DB00337 DB00864 DB00877
BioGrid ID 108570
GuidetoPHARMACOLOGY ID 2609
PharmGKB ID PA28153
KEGG ID hsa:2280
DIP ID DIP-29710N
STRING ID 9606.ENSP00000371138
IntAct ID P62942
DMDM
BRENDA 5.2.1.8
Reactome R-HSA-2173791 R-HSA-3656532 R-HSA-3656535 R-HSA-3645790 R-HSA-2173789
SignaLink P62942
BioCyc
Entrez Gene (Gene ID) 2280
BindingDB P62942

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.953 0.005 0.981 0.000 0.967 0.005 0.967 0.005 0.990 0.000 0.934 0.005 Download
Estate fingerprints 0.970 0.000 0.882 0.007 0.926 0.005 0.929 0.003 0.980 0.000 0.856 0.005 Download
MACCS fingerprints 0.940 0.000 0.948 0.003 0.944 0.005 0.944 0.005 0.990 0.000 0.891 0.006 Download
Daylight fingerprints 0.883 0.005 0.975 0.005 0.929 0.003 0.926 0.005 0.962 0.004 0.860 0.005 Download
ECFP2 fingerprints 0.986 0.005 0.994 0.004 0.990 0.000 0.990 0.000 1.000 0.000 0.980 0.000 Download
ECFP4 fingerprints 0.980 0.000 1.000 0.000 0.990 0.000 0.990 0.000 1.000 0.000 0.980 0.000 Download
ECFP6 fingerprints 0.974 0.005 1.000 0.000 0.989 0.003 0.989 0.003 1.000 0.000 0.974 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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