Target name

P63000: Ras-related C3 botulinum toxin substrate 1


  Protein function

Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion. In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3.

  Database links

Uniprot primary ID P63000
PDB ID 1RYH 1E96 4YON 1RYF 2WKQ 2WKR 1MH1 2H7V 3BJI 3SU8 1I4L 4GZM 4GZL 1I4D 1G4U 1I4T 1HE1 2NZ8 1FOE 3SBD 3SBE 3B13 2WKP 3SUA 2VRW 2YIN 2P2L 2RMK 3RYT 1HH4 3TH5 2FJU
DrugBank ID DB00514
BioGrid ID 111817
GuidetoPHARMACOLOGY ID
PharmGKB ID PA34162
KEGG ID hsa:5879
DIP ID DIP-29260N
STRING ID
IntAct ID P63000
DMDM 51702787
BRENDA
Reactome R-HSA-376172 R-HSA-445144 R-HSA-418885 R-HSA-2871796 R-HSA-428540 R-HSA-428543 R-HSA-5625900 R-HSA-114604 R-HSA-399954 R-HSA-5625740 R-HSA-5627123 R-HSA-5663220 R-HSA-5626467 R-HSA-4420097 R-HSA-389359 R-HSA-983231 R-HSA-193648 R-HSA-399955 R-HSA-5663213
SignaLink P63000
BioCyc
Entrez Gene (Gene ID) 5879
BindingDB P63000

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.556 0.007 0.916 0.007 0.736 0.005 0.674 0.005 0.829 0.010 0.498 0.008 Download
Estate fingerprints 0.787 0.021 0.783 0.015 0.785 0.012 0.787 0.013 0.875 0.005 0.575 0.022 Download
MACCS fingerprints 0.761 0.013 0.737 0.017 0.749 0.011 0.752 0.013 0.848 0.006 0.496 0.026 Download
Daylight fingerprints 0.439 0.007 0.987 0.011 0.713 0.005 0.603 0.009 0.759 0.014 0.501 0.015 Download
ECFP2 fingerprints 0.820 0.017 0.808 0.014 0.814 0.011 0.817 0.011 0.901 0.003 0.633 0.021 Download
ECFP4 fingerprints 0.777 0.014 0.879 0.012 0.828 0.010 0.821 0.012 0.916 0.005 0.659 0.022 Download
ECFP6 fingerprints 0.695 0.014 0.911 0.013 0.803 0.011 0.780 0.012 0.909 0.006 0.627 0.019 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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