Target name

P63001: Ras-related C3 botulinum toxin substrate 1


  Protein function

Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3.

  Database links

Uniprot primary ID P63001
PDB ID
DrugBank ID
BioGrid ID 202556
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID mmu:19353
DIP ID DIP-31545N
STRING ID 10090.ENSMUSP00000079380
IntAct ID P63001
DMDM
BRENDA
Reactome R-MMU-5663220 R-MMU-2424491 R-MMU-418885 R-MMU-442009 R-MMU-399955 R-MMU-3928664 R-MMU-445144 R-MMU-193648 R-MMU-389359 R-MMU-5687128 R-MMU-5668599 R-MMU-428540 R-MMU-5218920 R-MMU-428543 R-MMU-5627123 R-MMU-399954 R-MMU-5625900 R-MMU-114604 R-MMU-4086400
SignaLink
BioCyc
Entrez Gene (Gene ID) 19353
BindingDB P63001

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.626 0.015 0.906 0.013 0.766 0.011 0.730 0.016 0.817 0.005 0.559 0.023 Download
Estate fingerprints 0.794 0.016 0.838 0.015 0.816 0.011 0.812 0.010 0.895 0.005 0.636 0.021 Download
MACCS fingerprints 0.766 0.011 0.808 0.014 0.787 0.009 0.783 0.009 0.867 0.005 0.577 0.016 Download
Daylight fingerprints 0.559 0.025 0.861 0.011 0.710 0.014 0.657 0.018 0.753 0.009 0.438 0.027 Download
ECFP2 fingerprints 0.870 0.015 0.778 0.019 0.824 0.007 0.833 0.007 0.915 0.005 0.655 0.014 Download
ECFP4 fingerprints 0.798 0.015 0.858 0.023 0.828 0.016 0.827 0.015 0.920 0.000 0.663 0.034 Download
ECFP6 fingerprints 0.734 0.013 0.914 0.011 0.824 0.010 0.805 0.008 0.913 0.005 0.660 0.018 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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