Target name

Q02127: Dihydroorotate dehydrogenase (quinone), mitochondrial


  Protein function

Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.

  Database links

Uniprot primary ID Q02127
PDB ID 2WV8 4JS3 3U2O 3ZWT 3ZWS 2FQI 3KVK 4LS1 4LS0 4LS2 4IGH 2B0M 2FPT 2FPV 2FPY 2BXV 3W7R 2PRL 2PRM 2PRH 3FJL 3F1Q 4JTT 4JTU 4JTS 4JGD 1D3G 3G0X 3KVJ 3KVL 3KVM 4OQV 1D3H 3G0U 3FJ6
DrugBank ID DB01097 DB08880 DB01117
BioGrid ID 108068
GuidetoPHARMACOLOGY ID 2604
PharmGKB ID PA27327
KEGG ID hsa:1723
DIP ID
STRING ID 9606.ENSP00000219240
IntAct ID Q02127
DMDM 56405372
BRENDA 1.3.5.2 1.3.98.1
Reactome R-HSA-500753
SignaLink
BioCyc
Entrez Gene (Gene ID) 1723
BindingDB Q02127

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.915 0.007 0.953 0.005 0.934 0.005 0.931 0.003 0.970 0.000 0.867 0.007 Download
Estate fingerprints 0.912 0.006 0.892 0.000 0.902 0.004 0.902 0.004 0.960 0.000 0.803 0.005 Download
MACCS fingerprints 0.909 0.006 0.909 0.004 0.909 0.003 0.909 0.003 0.970 0.000 0.820 0.007 Download
Daylight fingerprints 0.790 0.008 0.978 0.000 0.884 0.005 0.874 0.005 0.960 0.000 0.784 0.005 Download
ECFP2 fingerprints 0.965 0.005 0.953 0.005 0.959 0.003 0.959 0.003 0.990 0.000 0.916 0.007 Download
ECFP4 fingerprints 0.947 0.005 0.963 0.000 0.955 0.005 0.955 0.005 0.991 0.003 0.914 0.007 Download
ECFP6 fingerprints 0.926 0.005 0.984 0.005 0.955 0.005 0.955 0.005 0.999 0.003 0.915 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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