Target name

Q05397: Focal adhesion kinase 1

  Protein function

Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription.

  Database links

Uniprot primary ID Q05397
PDB ID 3PXK 4EBW 4EBV 4Q9S 3BZ3 4I4E 1MP8 4I4F 4K9Y 3B71 4GU9 4GU6 4KAO 4KAB 2IJM 2ETM 2RA7 1K04 1K05 4K8A 1OW8 4NY0 1OW7 1OW6 3S9O
DrugBank ID
BioGrid ID 111719
PharmGKB ID PA33955
KEGG ID hsa:5747
STRING ID 9606.ENSP00000341189
IntAct ID Q05397
DMDM 3183518
Reactome R-HSA-418886 R-HSA-418885 R-HSA-5663213 R-HSA-2029482 R-HSA-372708 R-HSA-111465 R-HSA-354194 R-HSA-354192 R-HSA-3928662 R-HSA-375165 R-HSA-3928663 R-HSA-4420097 R-HSA-391160 R-HSA-5673001
SignaLink Q05397
Entrez Gene (Gene ID) 5747
BindingDB Q05397

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.691 0.003 0.839 0.008 0.765 0.005 0.745 0.005 0.857 0.005 0.539 0.009 Download
Estate fingerprints 0.713 0.007 0.727 0.005 0.720 0.005 0.718 0.006 0.791 0.003 0.439 0.009 Download
MACCS fingerprints 0.721 0.010 0.779 0.007 0.750 0.007 0.742 0.006 0.834 0.005 0.501 0.009 Download
Daylight fingerprints 0.619 0.009 0.897 0.007 0.758 0.004 0.720 0.007 0.812 0.004 0.537 0.009 Download
ECFP2 fingerprints 0.778 0.004 0.852 0.007 0.815 0.005 0.809 0.003 0.902 0.004 0.633 0.007 Download
ECFP4 fingerprints 0.695 0.005 0.935 0.006 0.815 0.005 0.788 0.004 0.910 0.000 0.645 0.008 Download
ECFP6 fingerprints 0.628 0.006 0.972 0.000 0.800 0.005 0.759 0.006 0.900 0.000 0.641 0.007 Download

  Download datasets

Positive dataset Negative dataset

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