Target name

Q07869: Peroxisome proliferator-activated receptor alpha


  Protein function

Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.

  Database links

Uniprot primary ID Q07869
PDB ID 3FEI 3KDT 3KDU 1I7G 3ET1 3G8I 4CI4 2NPA 3VI8 2REW 2ZNN 1K7L 3SP6 1KKQ 4BCR 2P54
DrugBank ID DB00636 DB01039 DB00328 DB01393 DB01241
BioGrid ID 111461
GuidetoPHARMACOLOGY ID 593
PharmGKB ID PA280
KEGG ID hsa:5465
DIP ID DIP-241N
STRING ID 9606.ENSP00000262735
IntAct ID Q07869
DMDM 3041727
BRENDA
Reactome R-HSA-1989781 R-HSA-383280 R-HSA-1368082 R-HSA-400206 R-HSA-381340 R-HSA-2426168 R-HSA-2151201 R-HSA-2032785 R-HSA-400253 R-HSA-1368108
SignaLink Q07869
BioCyc
Entrez Gene (Gene ID) 5465
BindingDB Q07869

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.870 0.000 0.950 0.000 0.910 0.000 0.900 0.000 0.960 0.000 0.810 0.000 Download
Estate fingerprints 0.900 0.000 0.880 0.000 0.890 0.000 0.890 0.000 0.960 0.000 0.780 0.000 Download
MACCS fingerprints 0.915 0.005 0.885 0.005 0.900 0.000 0.900 0.000 0.940 0.000 0.801 0.003 Download
Daylight fingerprints 0.869 0.003 0.931 0.003 0.900 0.000 0.897 0.005 0.940 0.000 0.799 0.003 Download
ECFP2 fingerprints 0.935 0.005 0.965 0.003 0.950 0.000 0.950 0.000 0.990 0.000 0.894 0.005 Download
ECFP4 fingerprints 0.938 0.004 0.982 0.000 0.960 0.000 0.957 0.005 0.990 0.000 0.915 0.005 Download
ECFP6 fingerprints 0.920 0.000 0.982 0.000 0.951 0.003 0.950 0.000 0.990 0.000 0.910 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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