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E-mail: biomed@csu.edu.cn
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Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoforms USO have no channel activity by themself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation.
| Uniprot primary ID | Q12809 |
| PDB ID | 1UJL 4HQA 2L0W 1BYW 2LE7 2L1M 2L4R 4HP9 |
| DrugBank ID | DB00661 DB01162 DB01142 DB00679 DB00590 DB06144 DB00204 |
| BioGrid ID | 109959 |
| GuidetoPHARMACOLOGY ID | 572 |
| PharmGKB ID | PA212 |
| KEGG ID | hsa:3757 |
| DIP ID | DIP-48929N |
| STRING ID | 9606.ENSP00000262186 |
| IntAct ID | Q12809 |
| DMDM | 7531135 |
| BRENDA | |
| Reactome | R-HSA-1296072 |
| SignaLink | Q12809 |
| BioCyc | |
| Entrez Gene (Gene ID) | 3757 |
| BindingDB | Q12809 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.739 | 0.003 | 0.721 | 0.000 | 0.730 | 0.000 | 0.731 | 0.003 | 0.810 | 0.000 | 0.461 | 0.003 | Download |
| Estate fingerprints | 0.750 | 0.000 | 0.654 | 0.004 | 0.702 | 0.004 | 0.720 | 0.000 | 0.770 | 0.000 | 0.410 | 0.000 | Download |
| MACCS fingerprints | 0.779 | 0.003 | 0.641 | 0.000 | 0.710 | 0.000 | 0.730 | 0.000 | 0.777 | 0.005 | 0.420 | 0.000 | Download |
| Daylight fingerprints | 0.682 | 0.004 | 0.738 | 0.000 | 0.710 | 0.000 | 0.700 | 0.000 | 0.760 | 0.000 | 0.417 | 0.005 | Download |
| ECFP2 fingerprints | 0.820 | 0.000 | 0.760 | 0.004 | 0.790 | 0.000 | 0.799 | 0.003 | 0.870 | 0.000 | 0.579 | 0.003 | Download |
| ECFP4 fingerprints | 0.799 | 0.003 | 0.821 | 0.003 | 0.810 | 0.000 | 0.810 | 0.000 | 0.890 | 0.000 | 0.621 | 0.003 | Download |
| ECFP6 fingerprints | 0.762 | 0.004 | 0.838 | 0.000 | 0.800 | 0.000 | 0.792 | 0.004 | 0.880 | 0.000 | 0.607 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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