Target name

Q12809: Potassium voltage-gated channel subfamily H member 2


  Protein function

Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoforms USO have no channel activity by themself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation.

  Database links

Uniprot primary ID Q12809
PDB ID 1UJL 4HQA 2L0W 1BYW 2LE7 2L1M 2L4R 4HP9
DrugBank ID DB00661 DB01162 DB01142 DB00679 DB00590 DB06144 DB00204
BioGrid ID 109959
GuidetoPHARMACOLOGY ID 572
PharmGKB ID PA212
KEGG ID hsa:3757
DIP ID DIP-48929N
STRING ID 9606.ENSP00000262186
IntAct ID Q12809
DMDM 7531135
BRENDA
Reactome R-HSA-1296072
SignaLink Q12809
BioCyc
Entrez Gene (Gene ID) 3757
BindingDB Q12809

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.739 0.003 0.721 0.000 0.730 0.000 0.731 0.003 0.810 0.000 0.461 0.003 Download
Estate fingerprints 0.750 0.000 0.654 0.004 0.702 0.004 0.720 0.000 0.770 0.000 0.410 0.000 Download
MACCS fingerprints 0.779 0.003 0.641 0.000 0.710 0.000 0.730 0.000 0.777 0.005 0.420 0.000 Download
Daylight fingerprints 0.682 0.004 0.738 0.000 0.710 0.000 0.700 0.000 0.760 0.000 0.417 0.005 Download
ECFP2 fingerprints 0.820 0.000 0.760 0.004 0.790 0.000 0.799 0.003 0.870 0.000 0.579 0.003 Download
ECFP4 fingerprints 0.799 0.003 0.821 0.003 0.810 0.000 0.810 0.000 0.890 0.000 0.621 0.003 Download
ECFP6 fingerprints 0.762 0.004 0.838 0.000 0.800 0.000 0.792 0.004 0.880 0.000 0.607 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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