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E-mail: biomed@csu.edu.cn
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Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes keratinocyte terminal differentiation. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization.
| Uniprot primary ID | Q13464 |
| PDB ID | 3TV7 5BML 2ETR 3V8S 3NCZ 3NDM 4YVC 2V55 2ETK 3O0Z 1S1C 4L2W 4W7P 2ESM 3D9V 4YVE 3TWJ |
| DrugBank ID | |
| BioGrid ID | 112020 |
| GuidetoPHARMACOLOGY ID | 1503 |
| PharmGKB ID | PA34623 |
| KEGG ID | hsa:6093 |
| DIP ID | |
| STRING ID | 9606.ENSP00000382697 |
| IntAct ID | Q13464 |
| DMDM | 47605999 |
| BRENDA | |
| Reactome | R-HSA-4420097 R-HSA-5627117 R-HSA-416572 R-HSA-416482 R-HSA-111465 R-HSA-3928663 R-HSA-3928662 |
| SignaLink | Q13464 |
| BioCyc | |
| Entrez Gene (Gene ID) | 6093 |
| BindingDB | Q13464 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.892 | 0.004 | 0.852 | 0.004 | 0.872 | 0.004 | 0.876 | 0.005 | 0.930 | 0.000 | 0.745 | 0.007 | Download |
| Estate fingerprints | 0.850 | 0.000 | 0.788 | 0.005 | 0.819 | 0.003 | 0.823 | 0.005 | 0.870 | 0.000 | 0.636 | 0.005 | Download |
| MACCS fingerprints | 0.883 | 0.005 | 0.723 | 0.004 | 0.803 | 0.005 | 0.820 | 0.000 | 0.878 | 0.004 | 0.614 | 0.005 | Download |
| Daylight fingerprints | 0.820 | 0.011 | 0.758 | 0.007 | 0.789 | 0.003 | 0.799 | 0.003 | 0.833 | 0.005 | 0.584 | 0.007 | Download |
| ECFP2 fingerprints | 0.930 | 0.007 | 0.844 | 0.005 | 0.887 | 0.005 | 0.892 | 0.004 | 0.954 | 0.005 | 0.778 | 0.008 | Download |
| ECFP4 fingerprints | 0.911 | 0.003 | 0.927 | 0.010 | 0.919 | 0.006 | 0.917 | 0.005 | 0.962 | 0.004 | 0.838 | 0.009 | Download |
| ECFP6 fingerprints | 0.890 | 0.007 | 0.970 | 0.005 | 0.930 | 0.005 | 0.927 | 0.005 | 0.960 | 0.000 | 0.862 | 0.008 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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