Target name

Q13464: Rho-associated protein kinase 1


  Protein function

Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes keratinocyte terminal differentiation. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization.

  Database links

Uniprot primary ID Q13464
PDB ID 3TV7 5BML 2ETR 3V8S 3NCZ 3NDM 4YVC 2V55 2ETK 3O0Z 1S1C 4L2W 4W7P 2ESM 3D9V 4YVE 3TWJ
DrugBank ID
BioGrid ID 112020
GuidetoPHARMACOLOGY ID 1503
PharmGKB ID PA34623
KEGG ID hsa:6093
DIP ID
STRING ID 9606.ENSP00000382697
IntAct ID Q13464
DMDM 47605999
BRENDA
Reactome R-HSA-4420097 R-HSA-5627117 R-HSA-416572 R-HSA-416482 R-HSA-111465 R-HSA-3928663 R-HSA-3928662
SignaLink Q13464
BioCyc
Entrez Gene (Gene ID) 6093
BindingDB Q13464

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.892 0.004 0.852 0.004 0.872 0.004 0.876 0.005 0.930 0.000 0.745 0.007 Download
Estate fingerprints 0.850 0.000 0.788 0.005 0.819 0.003 0.823 0.005 0.870 0.000 0.636 0.005 Download
MACCS fingerprints 0.883 0.005 0.723 0.004 0.803 0.005 0.820 0.000 0.878 0.004 0.614 0.005 Download
Daylight fingerprints 0.820 0.011 0.758 0.007 0.789 0.003 0.799 0.003 0.833 0.005 0.584 0.007 Download
ECFP2 fingerprints 0.930 0.007 0.844 0.005 0.887 0.005 0.892 0.004 0.954 0.005 0.778 0.008 Download
ECFP4 fingerprints 0.911 0.003 0.927 0.010 0.919 0.006 0.917 0.005 0.962 0.004 0.838 0.009 Download
ECFP6 fingerprints 0.890 0.007 0.970 0.005 0.930 0.005 0.927 0.005 0.960 0.000 0.862 0.008 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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