Target name

Q13946: High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A


  Protein function

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction.

  Database links

Uniprot primary ID Q13946
PDB ID 1ZKL 3G3N 4PM0 4Y2B
DrugBank ID DB00651 DB00920 DB00201
BioGrid ID 111176
GuidetoPHARMACOLOGY ID 1305
PharmGKB ID PA33139
KEGG ID hsa:5150
DIP ID
STRING ID 9606.ENSP00000385632
IntAct ID Q13946
DMDM 3182958
BRENDA 3.1.4.53
Reactome R-HSA-418555
SignaLink
BioCyc
Entrez Gene (Gene ID) 5150
BindingDB Q13946

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.909 0.003 0.983 0.004 0.946 0.005 0.945 0.005 0.980 0.000 0.895 0.005 Download
Estate fingerprints 0.752 0.004 0.746 0.006 0.749 0.006 0.749 0.006 0.863 0.005 0.497 0.011 Download
MACCS fingerprints 0.903 0.005 0.815 0.007 0.859 0.003 0.863 0.005 0.920 0.000 0.716 0.008 Download
Daylight fingerprints 0.922 0.004 0.862 0.006 0.892 0.004 0.894 0.005 0.920 0.000 0.783 0.007 Download
ECFP2 fingerprints 0.936 0.005 0.944 0.004 0.940 0.000 0.940 0.000 0.980 0.000 0.878 0.004 Download
ECFP4 fingerprints 0.937 0.005 0.981 0.005 0.959 0.003 0.959 0.003 0.990 0.000 0.921 0.006 Download
ECFP6 fingerprints 0.922 0.008 1.000 0.000 0.961 0.006 0.957 0.005 0.990 0.000 0.922 0.006 Download

  Download datasets

Positive dataset Negative dataset


The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn