G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
| Uniprot primary ID | Q14833 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | |
| GuidetoPHARMACOLOGY ID | 292 |
| PharmGKB ID | PA28993 |
| KEGG ID | hsa:2914 |
| DIP ID | |
| STRING ID | 9606.ENSP00000363296 |
| IntAct ID | |
| DMDM | 2495077 |
| BRENDA | |
| Reactome | R-HSA-418594 R-HSA-420499 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 2914 |
| BindingDB | Q14833 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.898 | 0.009 | 0.952 | 0.005 | 0.925 | 0.007 | 0.925 | 0.007 | 0.970 | 0.000 | 0.855 | 0.011 | Download |
| Estate fingerprints | 0.792 | 0.008 | 0.824 | 0.009 | 0.808 | 0.004 | 0.806 | 0.005 | 0.890 | 0.000 | 0.618 | 0.009 | Download |
| MACCS fingerprints | 0.866 | 0.005 | 0.834 | 0.008 | 0.850 | 0.005 | 0.854 | 0.005 | 0.920 | 0.000 | 0.700 | 0.011 | Download |
| Daylight fingerprints | 0.901 | 0.007 | 0.823 | 0.003 | 0.862 | 0.004 | 0.866 | 0.005 | 0.882 | 0.004 | 0.728 | 0.008 | Download |
| ECFP2 fingerprints | 0.965 | 0.005 | 0.853 | 0.007 | 0.909 | 0.006 | 0.914 | 0.005 | 0.980 | 0.000 | 0.824 | 0.011 | Download |
| ECFP4 fingerprints | 0.970 | 0.008 | 0.958 | 0.005 | 0.964 | 0.005 | 0.965 | 0.005 | 0.990 | 0.000 | 0.930 | 0.008 | Download |
| ECFP6 fingerprints | 0.967 | 0.005 | 0.975 | 0.003 | 0.971 | 0.003 | 0.971 | 0.003 | 0.990 | 0.000 | 0.938 | 0.006 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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