Target name

Q14833: Metabotropic glutamate receptor 4


  Protein function

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.

  Database links

Uniprot primary ID Q14833
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 292
PharmGKB ID PA28993
KEGG ID hsa:2914
DIP ID
STRING ID 9606.ENSP00000363296
IntAct ID
DMDM 2495077
BRENDA
Reactome R-HSA-418594 R-HSA-420499
SignaLink
BioCyc
Entrez Gene (Gene ID) 2914
BindingDB Q14833

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.898 0.009 0.952 0.005 0.925 0.007 0.925 0.007 0.970 0.000 0.855 0.011 Download
Estate fingerprints 0.792 0.008 0.824 0.009 0.808 0.004 0.806 0.005 0.890 0.000 0.618 0.009 Download
MACCS fingerprints 0.866 0.005 0.834 0.008 0.850 0.005 0.854 0.005 0.920 0.000 0.700 0.011 Download
Daylight fingerprints 0.901 0.007 0.823 0.003 0.862 0.004 0.866 0.005 0.882 0.004 0.728 0.008 Download
ECFP2 fingerprints 0.965 0.005 0.853 0.007 0.909 0.006 0.914 0.005 0.980 0.000 0.824 0.011 Download
ECFP4 fingerprints 0.970 0.008 0.958 0.005 0.964 0.005 0.965 0.005 0.990 0.000 0.930 0.008 Download
ECFP6 fingerprints 0.967 0.005 0.975 0.003 0.971 0.003 0.971 0.003 0.990 0.000 0.938 0.006 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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