Target name

Q15858: Sodium channel protein type 9 subunit alpha


  Protein function

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain (By similarity).

  Database links

Uniprot primary ID Q15858
PDB ID
DrugBank ID DB06218 DB00313 DB06201 DB00243 DB00909 DB00281
BioGrid ID
GuidetoPHARMACOLOGY ID 584
PharmGKB ID PA35010
KEGG ID hsa:6335
DIP ID
STRING ID 9606.ENSP00000386306
IntAct ID
DMDM 327478559
BRENDA
Reactome R-HSA-445095
SignaLink
BioCyc
Entrez Gene (Gene ID) 6335
BindingDB Q15858

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.820 0.000 0.974 0.005 0.897 0.005 0.888 0.004 0.969 0.003 0.798 0.006 Download
Estate fingerprints 0.901 0.006 0.831 0.008 0.866 0.005 0.871 0.006 0.940 0.000 0.736 0.010 Download
MACCS fingerprints 0.904 0.005 0.812 0.007 0.858 0.004 0.866 0.005 0.940 0.000 0.721 0.007 Download
Daylight fingerprints 0.769 0.009 0.993 0.003 0.881 0.003 0.864 0.005 0.887 0.005 0.780 0.007 Download
ECFP2 fingerprints 0.937 0.005 0.961 0.000 0.949 0.003 0.949 0.003 0.990 0.000 0.901 0.007 Download
ECFP4 fingerprints 0.938 0.004 1.000 0.005 0.969 0.003 0.968 0.004 0.990 0.000 0.938 0.008 Download
ECFP6 fingerprints 0.944 0.005 1.000 0.000 0.972 0.004 0.972 0.004 0.990 0.000 0.946 0.005 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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