The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
E-mail: biomed@csu.edu.cn
 |
 |
 |
 |
 |
 |
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP (PubMed:8530505). Specifically regulates nitric-oxide-generated cGMP (By similarity).
| Uniprot primary ID | Q28156 |
| PDB ID | 1FL4 3JAB |
| DrugBank ID | |
| BioGrid ID | |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | |
| KEGG ID | bta:281972 |
| DIP ID | |
| STRING ID | 9913.ENSBTAP00000014479 |
| IntAct ID | |
| DMDM | |
| BRENDA | |
| Reactome | R-BTA-418457 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 281972 |
| BindingDB | Q28156 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.881 | 0.003 | 0.999 | 0.000 | 0.940 | 0.000 | 0.934 | 0.005 | 0.973 | 0.005 | 0.881 | 0.003 | Download |
| Estate fingerprints | 0.808 | 0.014 | 0.850 | 0.008 | 0.829 | 0.009 | 0.822 | 0.008 | 0.921 | 0.003 | 0.652 | 0.015 | Download |
| MACCS fingerprints | 0.908 | 0.008 | 0.814 | 0.008 | 0.861 | 0.006 | 0.868 | 0.004 | 0.930 | 0.000 | 0.728 | 0.009 | Download |
| Daylight fingerprints | 0.900 | 0.000 | 0.940 | 0.005 | 0.920 | 0.000 | 0.920 | 0.000 | 0.937 | 0.005 | 0.847 | 0.005 | Download |
| ECFP2 fingerprints | 0.940 | 0.000 | 0.980 | 0.004 | 0.960 | 0.000 | 0.960 | 0.000 | 0.990 | 0.000 | 0.923 | 0.005 | Download |
| ECFP4 fingerprints | 0.933 | 0.005 | 0.993 | 0.000 | 0.963 | 0.005 | 0.963 | 0.005 | 0.991 | 0.003 | 0.933 | 0.005 | Download |
| ECFP6 fingerprints | 0.920 | 0.000 | 1.000 | 0.000 | 0.960 | 0.000 | 0.960 | 0.000 | 0.989 | 0.003 | 0.930 | 0.000 | Download |
| Positive dataset | Negative dataset |
The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
E-mail: biomed@csu.edu.cn
| |
|
|
| |
|
|