Target name

Q28156: cGMP-specific 3',5'-cyclic phosphodiesterase


  Protein function

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP (PubMed:8530505). Specifically regulates nitric-oxide-generated cGMP (By similarity).

  Database links

Uniprot primary ID Q28156
PDB ID 1FL4 3JAB
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID bta:281972
DIP ID
STRING ID 9913.ENSBTAP00000014479
IntAct ID
DMDM
BRENDA
Reactome R-BTA-418457
SignaLink
BioCyc
Entrez Gene (Gene ID) 281972
BindingDB Q28156

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.881 0.003 0.999 0.000 0.940 0.000 0.934 0.005 0.973 0.005 0.881 0.003 Download
Estate fingerprints 0.808 0.014 0.850 0.008 0.829 0.009 0.822 0.008 0.921 0.003 0.652 0.015 Download
MACCS fingerprints 0.908 0.008 0.814 0.008 0.861 0.006 0.868 0.004 0.930 0.000 0.728 0.009 Download
Daylight fingerprints 0.900 0.000 0.940 0.005 0.920 0.000 0.920 0.000 0.937 0.005 0.847 0.005 Download
ECFP2 fingerprints 0.940 0.000 0.980 0.004 0.960 0.000 0.960 0.000 0.990 0.000 0.923 0.005 Download
ECFP4 fingerprints 0.933 0.005 0.993 0.000 0.963 0.005 0.963 0.005 0.991 0.003 0.933 0.005 Download
ECFP6 fingerprints 0.920 0.000 1.000 0.000 0.960 0.000 0.960 0.000 0.989 0.003 0.930 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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