Target name

Q29010: Endothelin-1 receptor


  Protein function

Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity).

  Database links

Uniprot primary ID Q29010
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID ssc:397457
DIP ID
STRING ID 9823.ENSSSCP00000009635
IntAct ID
DMDM
BRENDA
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 397457
BindingDB Q29010

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.960 0.009 0.988 0.000 0.974 0.005 0.974 0.005 0.990 0.000 0.950 0.009 Download
Estate fingerprints 0.943 0.007 0.877 0.007 0.910 0.005 0.911 0.003 0.960 0.000 0.817 0.009 Download
MACCS fingerprints 0.860 0.012 0.906 0.007 0.883 0.007 0.881 0.009 0.940 0.000 0.767 0.009 Download
Daylight fingerprints 0.970 0.000 0.990 0.000 0.980 0.000 0.980 0.000 0.990 0.000 0.969 0.003 Download
ECFP2 fingerprints 0.970 0.000 0.970 0.005 0.970 0.000 0.970 0.000 0.990 0.000 0.943 0.005 Download
ECFP4 fingerprints 0.970 0.000 0.990 0.003 0.980 0.000 0.980 0.000 0.990 0.000 0.961 0.003 Download
ECFP6 fingerprints 0.970 0.000 0.990 0.000 0.980 0.000 0.980 0.000 0.990 0.000 0.962 0.004 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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