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E-mail: biomed@csu.edu.cn
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Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity).
| Uniprot primary ID | Q29010 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | |
| KEGG ID | ssc:397457 |
| DIP ID | |
| STRING ID | 9823.ENSSSCP00000009635 |
| IntAct ID | |
| DMDM | |
| BRENDA | |
| Reactome | |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 397457 |
| BindingDB | Q29010 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.960 | 0.009 | 0.988 | 0.000 | 0.974 | 0.005 | 0.974 | 0.005 | 0.990 | 0.000 | 0.950 | 0.009 | Download |
| Estate fingerprints | 0.943 | 0.007 | 0.877 | 0.007 | 0.910 | 0.005 | 0.911 | 0.003 | 0.960 | 0.000 | 0.817 | 0.009 | Download |
| MACCS fingerprints | 0.860 | 0.012 | 0.906 | 0.007 | 0.883 | 0.007 | 0.881 | 0.009 | 0.940 | 0.000 | 0.767 | 0.009 | Download |
| Daylight fingerprints | 0.970 | 0.000 | 0.990 | 0.000 | 0.980 | 0.000 | 0.980 | 0.000 | 0.990 | 0.000 | 0.969 | 0.003 | Download |
| ECFP2 fingerprints | 0.970 | 0.000 | 0.970 | 0.005 | 0.970 | 0.000 | 0.970 | 0.000 | 0.990 | 0.000 | 0.943 | 0.005 | Download |
| ECFP4 fingerprints | 0.970 | 0.000 | 0.990 | 0.003 | 0.980 | 0.000 | 0.980 | 0.000 | 0.990 | 0.000 | 0.961 | 0.003 | Download |
| ECFP6 fingerprints | 0.970 | 0.000 | 0.990 | 0.000 | 0.980 | 0.000 | 0.980 | 0.000 | 0.990 | 0.000 | 0.962 | 0.004 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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