Target name

Q920D2: Dihydrofolate reductase


  Protein function

Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1 (By similarity).

  Database links

Uniprot primary ID Q920D2
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID rno:24312
DIP ID
STRING ID 10116.ENSRNOP00000018259
IntAct ID
DMDM
BRENDA 1.5.1.3
Reactome R-RNO-69205 R-RNO-1474151 R-RNO-196757 R-RNO-113510
SignaLink
BioCyc
Entrez Gene (Gene ID) 24312
BindingDB Q920D2

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.970 0.000 0.990 0.000 0.980 0.000 0.980 0.000 1.000 0.000 0.965 0.005 Download
Estate fingerprints 0.930 0.000 0.952 0.000 0.941 0.003 0.941 0.003 0.990 0.000 0.890 0.000 Download
MACCS fingerprints 0.969 0.003 0.971 0.005 0.970 0.000 0.970 0.000 1.000 0.000 0.940 0.000 Download
Daylight fingerprints 0.917 0.005 1.000 0.000 0.959 0.003 0.959 0.003 1.000 0.000 0.919 0.003 Download
ECFP2 fingerprints 0.990 0.000 0.990 0.004 0.990 0.000 0.990 0.000 1.000 0.000 0.982 0.004 Download
ECFP4 fingerprints 0.990 0.000 0.990 0.000 0.990 0.000 0.990 0.000 1.000 0.000 0.983 0.005 Download
ECFP6 fingerprints 0.990 0.000 0.990 0.000 0.990 0.000 0.990 0.000 1.000 0.000 0.990 0.000 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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