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E-mail: biomed@csu.edu.cn
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Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.
| Uniprot primary ID | Q92769 |
| PDB ID | 3MAX 4LXZ 4LY1 |
| DrugBank ID | DB01223 DB00313 DB00227 DB02546 DB01303 DB00277 |
| BioGrid ID | 109316 |
| GuidetoPHARMACOLOGY ID | 2616 |
| PharmGKB ID | PA29227 |
| KEGG ID | hsa:3066 |
| DIP ID | DIP-24220N |
| STRING ID | 9606.ENSP00000430432 |
| IntAct ID | Q92769 |
| DMDM | 68068066 |
| BRENDA | 3.5.1.98 |
| Reactome | R-HSA-427413 R-HSA-2644606 R-HSA-193670 R-HSA-2122947 R-HSA-3214815 R-HSA-73762 R-HSA-983231 R-HSA-2894862 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 3066 |
| BindingDB | Q92769 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.860 | 0.000 | 0.920 | 0.005 | 0.890 | 0.000 | 0.883 | 0.005 | 0.960 | 0.000 | 0.775 | 0.005 | Download |
| Estate fingerprints | 0.892 | 0.004 | 0.810 | 0.004 | 0.851 | 0.003 | 0.855 | 0.007 | 0.934 | 0.005 | 0.702 | 0.009 | Download |
| MACCS fingerprints | 0.832 | 0.004 | 0.926 | 0.000 | 0.879 | 0.003 | 0.872 | 0.004 | 0.960 | 0.000 | 0.761 | 0.006 | Download |
| Daylight fingerprints | 0.727 | 0.005 | 0.793 | 0.005 | 0.760 | 0.000 | 0.750 | 0.000 | 0.810 | 0.000 | 0.517 | 0.005 | Download |
| ECFP2 fingerprints | 0.966 | 0.005 | 0.916 | 0.007 | 0.941 | 0.003 | 0.941 | 0.003 | 0.990 | 0.000 | 0.882 | 0.009 | Download |
| ECFP4 fingerprints | 0.962 | 0.004 | 0.940 | 0.005 | 0.951 | 0.003 | 0.952 | 0.004 | 0.990 | 0.000 | 0.906 | 0.005 | Download |
| ECFP6 fingerprints | 0.925 | 0.008 | 0.975 | 0.005 | 0.950 | 0.005 | 0.948 | 0.006 | 0.990 | 0.000 | 0.898 | 0.006 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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