Target name

Q92769: Histone deacetylase 2


  Protein function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.

  Database links

Uniprot primary ID Q92769
PDB ID 3MAX 4LXZ 4LY1
DrugBank ID DB01223 DB00313 DB00227 DB02546 DB01303 DB00277
BioGrid ID 109316
GuidetoPHARMACOLOGY ID 2616
PharmGKB ID PA29227
KEGG ID hsa:3066
DIP ID DIP-24220N
STRING ID 9606.ENSP00000430432
IntAct ID Q92769
DMDM 68068066
BRENDA 3.5.1.98
Reactome R-HSA-427413 R-HSA-2644606 R-HSA-193670 R-HSA-2122947 R-HSA-3214815 R-HSA-73762 R-HSA-983231 R-HSA-2894862
SignaLink
BioCyc
Entrez Gene (Gene ID) 3066
BindingDB Q92769

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.860 0.000 0.920 0.005 0.890 0.000 0.883 0.005 0.960 0.000 0.775 0.005 Download
Estate fingerprints 0.892 0.004 0.810 0.004 0.851 0.003 0.855 0.007 0.934 0.005 0.702 0.009 Download
MACCS fingerprints 0.832 0.004 0.926 0.000 0.879 0.003 0.872 0.004 0.960 0.000 0.761 0.006 Download
Daylight fingerprints 0.727 0.005 0.793 0.005 0.760 0.000 0.750 0.000 0.810 0.000 0.517 0.005 Download
ECFP2 fingerprints 0.966 0.005 0.916 0.007 0.941 0.003 0.941 0.003 0.990 0.000 0.882 0.009 Download
ECFP4 fingerprints 0.962 0.004 0.940 0.005 0.951 0.003 0.952 0.004 0.990 0.000 0.906 0.005 Download
ECFP6 fingerprints 0.925 0.008 0.975 0.005 0.950 0.005 0.948 0.006 0.990 0.000 0.898 0.006 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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