Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine).
| Uniprot primary ID | Q92847 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | |
| GuidetoPHARMACOLOGY ID | 246 |
| PharmGKB ID | PA28677 |
| KEGG ID | hsa:2693 |
| DIP ID | |
| STRING ID | 9606.ENSP00000241256 |
| IntAct ID | |
| DMDM | 2494998 |
| BRENDA | |
| Reactome | R-HSA-375276 R-HSA-416476 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 2693 |
| BindingDB | Q92847 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.840 | 0.000 | 0.894 | 0.000 | 0.867 | 0.005 | 0.861 | 0.003 | 0.940 | 0.000 | 0.733 | 0.005 | Download |
| Estate fingerprints | 0.841 | 0.003 | 0.755 | 0.005 | 0.798 | 0.004 | 0.806 | 0.005 | 0.880 | 0.000 | 0.597 | 0.005 | Download |
| MACCS fingerprints | 0.835 | 0.005 | 0.745 | 0.003 | 0.790 | 0.000 | 0.800 | 0.000 | 0.880 | 0.000 | 0.585 | 0.005 | Download |
| Daylight fingerprints | 0.828 | 0.004 | 0.800 | 0.003 | 0.814 | 0.005 | 0.819 | 0.003 | 0.869 | 0.003 | 0.629 | 0.003 | Download |
| ECFP2 fingerprints | 0.860 | 0.000 | 0.940 | 0.000 | 0.900 | 0.000 | 0.898 | 0.004 | 0.970 | 0.000 | 0.803 | 0.005 | Download |
| ECFP4 fingerprints | 0.887 | 0.005 | 0.973 | 0.000 | 0.930 | 0.000 | 0.924 | 0.005 | 0.980 | 0.000 | 0.860 | 0.000 | Download |
| ECFP6 fingerprints | 0.822 | 0.004 | 0.976 | 0.000 | 0.899 | 0.003 | 0.890 | 0.000 | 0.980 | 0.000 | 0.803 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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