Target name

Q92847: Growth hormone secretagogue receptor type 1


  Protein function

Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine).

  Database links

Uniprot primary ID Q92847
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 246
PharmGKB ID PA28677
KEGG ID hsa:2693
DIP ID
STRING ID 9606.ENSP00000241256
IntAct ID
DMDM 2494998
BRENDA
Reactome R-HSA-375276 R-HSA-416476
SignaLink
BioCyc
Entrez Gene (Gene ID) 2693
BindingDB Q92847

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.840 0.000 0.894 0.000 0.867 0.005 0.861 0.003 0.940 0.000 0.733 0.005 Download
Estate fingerprints 0.841 0.003 0.755 0.005 0.798 0.004 0.806 0.005 0.880 0.000 0.597 0.005 Download
MACCS fingerprints 0.835 0.005 0.745 0.003 0.790 0.000 0.800 0.000 0.880 0.000 0.585 0.005 Download
Daylight fingerprints 0.828 0.004 0.800 0.003 0.814 0.005 0.819 0.003 0.869 0.003 0.629 0.003 Download
ECFP2 fingerprints 0.860 0.000 0.940 0.000 0.900 0.000 0.898 0.004 0.970 0.000 0.803 0.005 Download
ECFP4 fingerprints 0.887 0.005 0.973 0.000 0.930 0.000 0.924 0.005 0.980 0.000 0.860 0.000 Download
ECFP6 fingerprints 0.822 0.004 0.976 0.000 0.899 0.003 0.890 0.000 0.980 0.000 0.803 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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