Target name

Q969F8: KiSS-1 receptor


  Protein function

Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins.

  Database links

Uniprot primary ID Q969F8
PDB ID
DrugBank ID
BioGrid ID 124162
GuidetoPHARMACOLOGY ID 266
PharmGKB ID PA28899
KEGG ID hsa:84634
DIP ID
STRING ID 9606.ENSP00000234371
IntAct ID Q969F8
DMDM 125987836
BRENDA
Reactome R-HSA-375276 R-HSA-416476
SignaLink
BioCyc
Entrez Gene (Gene ID) 84634
BindingDB Q969F8

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.980 0.000 0.980 0.000 0.980 0.000 0.980 0.000 0.990 0.000 0.970 0.000 Download
Estate fingerprints 0.980 0.000 0.926 0.008 0.953 0.007 0.954 0.005 0.990 0.000 0.907 0.007 Download
MACCS fingerprints 0.936 0.005 0.906 0.004 0.921 0.006 0.921 0.006 0.971 0.003 0.840 0.007 Download
Daylight fingerprints 0.979 0.003 0.981 0.000 0.980 0.000 0.980 0.000 0.990 0.000 0.969 0.003 Download
ECFP2 fingerprints 0.980 0.000 0.980 0.000 0.980 0.000 0.980 0.000 0.990 0.000 0.970 0.000 Download
ECFP4 fingerprints 0.980 0.000 0.980 0.000 0.980 0.000 0.980 0.000 0.980 0.000 0.970 0.000 Download
ECFP6 fingerprints 0.980 0.000 0.980 0.000 0.980 0.000 0.980 0.000 0.980 0.000 0.970 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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 E-mail: biomed@csu.edu.cn