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E-mail: biomed@csu.edu.cn
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Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.
| Uniprot primary ID | Q99500 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | 108227 |
| GuidetoPHARMACOLOGY ID | 277 |
| PharmGKB ID | PA162402362 |
| KEGG ID | hsa:1903 |
| DIP ID | |
| STRING ID | 9606.ENSP00000350878 |
| IntAct ID | Q99500 |
| DMDM | 42560554 |
| BRENDA | |
| Reactome | R-HSA-419408 R-HSA-418594 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 1903 |
| BindingDB | Q99500 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.821 | 0.003 | 0.941 | 0.003 | 0.881 | 0.003 | 0.876 | 0.005 | 0.930 | 0.000 | 0.772 | 0.004 | Download |
| Estate fingerprints | 0.830 | 0.005 | 0.770 | 0.005 | 0.800 | 0.000 | 0.806 | 0.005 | 0.878 | 0.004 | 0.597 | 0.005 | Download |
| MACCS fingerprints | 0.835 | 0.005 | 0.785 | 0.005 | 0.810 | 0.000 | 0.815 | 0.005 | 0.890 | 0.000 | 0.622 | 0.008 | Download |
| Daylight fingerprints | 0.562 | 0.006 | 0.978 | 0.000 | 0.770 | 0.000 | 0.711 | 0.006 | 0.906 | 0.005 | 0.597 | 0.007 | Download |
| ECFP2 fingerprints | 0.867 | 0.005 | 0.933 | 0.004 | 0.900 | 0.000 | 0.900 | 0.000 | 0.950 | 0.000 | 0.807 | 0.005 | Download |
| ECFP4 fingerprints | 0.850 | 0.000 | 0.970 | 0.005 | 0.910 | 0.000 | 0.909 | 0.003 | 0.960 | 0.000 | 0.833 | 0.005 | Download |
| ECFP6 fingerprints | 0.840 | 0.000 | 0.984 | 0.000 | 0.912 | 0.004 | 0.910 | 0.000 | 0.960 | 0.000 | 0.840 | 0.000 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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