Target name

Q99500: Sphingosine 1-phosphate receptor 3


  Protein function

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.

  Database links

Uniprot primary ID Q99500
PDB ID
DrugBank ID
BioGrid ID 108227
GuidetoPHARMACOLOGY ID 277
PharmGKB ID PA162402362
KEGG ID hsa:1903
DIP ID
STRING ID 9606.ENSP00000350878
IntAct ID Q99500
DMDM 42560554
BRENDA
Reactome R-HSA-419408 R-HSA-418594
SignaLink
BioCyc
Entrez Gene (Gene ID) 1903
BindingDB Q99500

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.821 0.003 0.941 0.003 0.881 0.003 0.876 0.005 0.930 0.000 0.772 0.004 Download
Estate fingerprints 0.830 0.005 0.770 0.005 0.800 0.000 0.806 0.005 0.878 0.004 0.597 0.005 Download
MACCS fingerprints 0.835 0.005 0.785 0.005 0.810 0.000 0.815 0.005 0.890 0.000 0.622 0.008 Download
Daylight fingerprints 0.562 0.006 0.978 0.000 0.770 0.000 0.711 0.006 0.906 0.005 0.597 0.007 Download
ECFP2 fingerprints 0.867 0.005 0.933 0.004 0.900 0.000 0.900 0.000 0.950 0.000 0.807 0.005 Download
ECFP4 fingerprints 0.850 0.000 0.970 0.005 0.910 0.000 0.909 0.003 0.960 0.000 0.833 0.005 Download
ECFP6 fingerprints 0.840 0.000 0.984 0.000 0.912 0.004 0.910 0.000 0.960 0.000 0.840 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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