Target name

Q99705: Melanin-concentrating hormone receptor 1


  Protein function

Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.

  Database links

Uniprot primary ID Q99705
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 280
PharmGKB ID PA28867
KEGG ID hsa:2847
DIP ID
STRING ID 9606.ENSP00000249016
IntAct ID
DMDM 33860175
BRENDA
Reactome R-HSA-418594 R-HSA-5620922 R-HSA-375276 R-HSA-416476
SignaLink
BioCyc
Entrez Gene (Gene ID) 2847
BindingDB Q99705

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.910 0.000 0.830 0.000 0.870 0.000 0.879 0.003 0.945 0.005 0.741 0.003 Download
Estate fingerprints 0.830 0.000 0.726 0.000 0.778 0.004 0.790 0.000 0.850 0.000 0.555 0.005 Download
MACCS fingerprints 0.840 0.000 0.720 0.000 0.780 0.000 0.790 0.000 0.870 0.000 0.560 0.000 Download
Daylight fingerprints 0.800 0.000 0.860 0.000 0.830 0.000 0.830 0.000 0.900 0.000 0.668 0.004 Download
ECFP2 fingerprints 0.920 0.000 0.900 0.000 0.910 0.000 0.910 0.000 0.970 0.000 0.819 0.003 Download
ECFP4 fingerprints 0.929 0.003 0.955 0.000 0.942 0.004 0.940 0.000 0.990 0.000 0.890 0.000 Download
ECFP6 fingerprints 0.899 0.003 0.975 0.000 0.937 0.005 0.930 0.000 0.990 0.000 0.873 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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