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E-mail: biomed@csu.edu.cn
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Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility.
| Uniprot primary ID | Q9BY41 |
| PDB ID | 3MZ6 3MZ7 3MZ4 4QA5 4QA2 3MZ3 4QA0 4QA1 3EWF 1W22 4QA4 3F0R 1T64 1T67 4QA3 4QA7 3EW8 2V5X 3SFH 3SFF 2V5W 1VKG 3RQD 1T69 4RN0 4RN1 4RN2 4QA6 3F07 3F06 3EZT 3EZP |
| DrugBank ID | DB02546 |
| BioGrid ID | 120968 |
| GuidetoPHARMACOLOGY ID | 2619 |
| PharmGKB ID | PA37766 |
| KEGG ID | hsa:55869 |
| DIP ID | |
| STRING ID | 9606.ENSP00000362674 |
| IntAct ID | Q9BY41 |
| DMDM | 29839394 |
| BRENDA | 3.5.1.98 |
| Reactome | R-HSA-2500257 R-HSA-2467813 R-HSA-2644606 R-HSA-2122947 R-HSA-3214815 R-HSA-2894862 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 55869 |
| BindingDB | Q9BY41 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.885 | 0.005 | 0.915 | 0.005 | 0.900 | 0.005 | 0.899 | 0.003 | 0.960 | 0.000 | 0.802 | 0.006 | Download |
| Estate fingerprints | 0.909 | 0.003 | 0.851 | 0.005 | 0.880 | 0.000 | 0.885 | 0.005 | 0.940 | 0.000 | 0.765 | 0.005 | Download |
| MACCS fingerprints | 0.882 | 0.004 | 0.958 | 0.003 | 0.920 | 0.000 | 0.920 | 0.000 | 0.960 | 0.000 | 0.846 | 0.005 | Download |
| Daylight fingerprints | 0.860 | 0.000 | 0.794 | 0.003 | 0.827 | 0.005 | 0.830 | 0.000 | 0.850 | 0.000 | 0.654 | 0.005 | Download |
| ECFP2 fingerprints | 0.950 | 0.000 | 0.956 | 0.004 | 0.953 | 0.005 | 0.953 | 0.005 | 0.990 | 0.000 | 0.908 | 0.004 | Download |
| ECFP4 fingerprints | 0.950 | 0.000 | 0.970 | 0.000 | 0.960 | 0.000 | 0.960 | 0.000 | 0.990 | 0.000 | 0.924 | 0.005 | Download |
| ECFP6 fingerprints | 0.919 | 0.006 | 0.989 | 0.000 | 0.954 | 0.005 | 0.952 | 0.004 | 0.990 | 0.000 | 0.912 | 0.004 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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