Target name

Q9BY41: Histone deacetylase 8


  Protein function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility.

  Database links

Uniprot primary ID Q9BY41
PDB ID 3MZ6 3MZ7 3MZ4 4QA5 4QA2 3MZ3 4QA0 4QA1 3EWF 1W22 4QA4 3F0R 1T64 1T67 4QA3 4QA7 3EW8 2V5X 3SFH 3SFF 2V5W 1VKG 3RQD 1T69 4RN0 4RN1 4RN2 4QA6 3F07 3F06 3EZT 3EZP
DrugBank ID DB02546
BioGrid ID 120968
GuidetoPHARMACOLOGY ID 2619
PharmGKB ID PA37766
KEGG ID hsa:55869
DIP ID
STRING ID 9606.ENSP00000362674
IntAct ID Q9BY41
DMDM 29839394
BRENDA 3.5.1.98
Reactome R-HSA-2500257 R-HSA-2467813 R-HSA-2644606 R-HSA-2122947 R-HSA-3214815 R-HSA-2894862
SignaLink
BioCyc
Entrez Gene (Gene ID) 55869
BindingDB Q9BY41

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.885 0.005 0.915 0.005 0.900 0.005 0.899 0.003 0.960 0.000 0.802 0.006 Download
Estate fingerprints 0.909 0.003 0.851 0.005 0.880 0.000 0.885 0.005 0.940 0.000 0.765 0.005 Download
MACCS fingerprints 0.882 0.004 0.958 0.003 0.920 0.000 0.920 0.000 0.960 0.000 0.846 0.005 Download
Daylight fingerprints 0.860 0.000 0.794 0.003 0.827 0.005 0.830 0.000 0.850 0.000 0.654 0.005 Download
ECFP2 fingerprints 0.950 0.000 0.956 0.004 0.953 0.005 0.953 0.005 0.990 0.000 0.908 0.004 Download
ECFP4 fingerprints 0.950 0.000 0.970 0.000 0.960 0.000 0.960 0.000 0.990 0.000 0.924 0.005 Download
ECFP6 fingerprints 0.919 0.006 0.989 0.000 0.954 0.005 0.952 0.004 0.990 0.000 0.912 0.004 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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